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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C, protect from light, stored under nitrogen
- 英文名：
WR-1065
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
31098-42-7
- 规格：
5 mg/10 mg
| 规格： | 5 mg | 产品价格： | ￥562.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥900.0 |
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Amifostine thiol
CAS No. : 31098-42-7
MCE 国际站：Amifostine thiol
产品活性：Amifostine thiol (WR-1065) 是细胞保护剂 Amifostine (HY-B0639) 的活性代谢物。Amifostine thiol 是一种具有辐射防护能力的细胞保护剂。Amifostine thiol 通过 JNK 依赖的信号通路激活 p53。
研究领域：Apoptosis
作用靶点：MDM-2/p53
In Vitro: Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures.
Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation.
Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation.
Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability.
Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment.
Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage.
Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81.
Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.
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文献和实验cysteines are blocked.· All remaining cysteines (presumably only those that are denitrosylated) are denitrosylated.· The now-free thiol groups are then biotinylated.· Biotinylated proteins are detected by SDS-PAGE and western blot analysis
Disulfide Conjugation of Peptides to Oligonucleotides and Their Analogs
may have advantages for cell delivery, since it is likely to be cleaved within cells, thus releasing the oligonucleotide cargo. It is straightforward to introduce thiol functionalities into both oligonucleotide and peptide components suitable for disulfide conjugation
antibody. FEBS Lett. 1998, 421(1): 50. 11 Liu SC, Murley JS, Woloschak G, et al. Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine. Carcinogenesis. 1997, 18(12): 2457. 12 Van-Waardenburg RC, Meijer C
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