Butaprost布他前列素,69685-22-9

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Butaprost

CAS No. : 69685-22-9

MCE 国际站：Butaprost

产品活性：Butaprost 是一种选择性前列腺素 E 受体 (EP2) 激动剂，对鼠类 EP2 受体的 EC₅₀ 值为 33 nM，K_i 值为 2.4 μM。Butaprost 对鼠类 EP1，EP3 和 EP4 受体的活性较低。Butaprost 通过阻碍 TGF-β/Smad2 信号传导来减轻纤维化。

研究领域：GPCR/G Protein  |  TGF-beta/Smad  |  Stem Cell/Wnt

作用靶点：Prostaglandin Receptor  |  TGF-beta/Smad

In Vitro: Butaprost (1-100 nM; 0.5-24 hours) induces about a five-fold upregulation of Nur77 mRNA expression in hEP2-HEK293/EBNA cells in a dose- and time-dependent. Butaprost upregulated Nur77 gene expression through the PKC pathway.
Butaprost (50 μM; 24 hours) reduces TGF-β-induced fibronectin (FN) expression, Smad2 phosphorylation and epithelial-mesenchymal transition in Madin-Darby Canine Kidney (MDCK) cells.

In Vivo: Butaprost (1-4 mg/kg; intraperitoneal injection; twice daily; for 7 days) treatment attenuates the development of fibrosis in mice that underwent unilateral ureteral obstruction surgery, as illustrated by a reduction in the gene and protein expression of α-smooth muscle actin, fibronectin and collagen 1A1.

相关产品：Prostaglandin E2  |  Pirfenidone  |  EIPA  |  SIS3  |  Prostaglandin E1  |  Halofuginone  |  Kartogenin  |  SRI-011381 hydrochloride  |  Asiaticoside  |  Tranilast  |  Trimethylamine N-oxide  |  PF-04418948  |  U-46619  |  Oxymatrine  |  Iloprost  |  Prostaglandin D2  |  ONO-AE3-208  |  Dinoprost  |  Hydrochlorothiazide  |  Alantolactone  |  Palupiprant  |  Latanoprost  |  Selexipag  |  Ponsegromab  |  EMT inhibitor-1  |  16,16-Dimethyl prostaglandin E2  |  Treprostinil

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds