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1838622-25-5
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电询
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EST73502
CAS No. : 1838622-25-5
MCE 国际站：EST73502
产品活性：EST73502 是一种选择性的，具有口服活性的，可透过血脑屏障的 μ-opioid 受体 (μ-opioid receptor/MOR) 激动剂和 σ1 受体(σ1R) 拮抗剂，对 MOR 和 σ1R 作用的 Ki 值分别为 64 nM 和 118 nM。EST73502 可用于缓解疼痛研究。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Opioid Receptor | Sigma Receptor
In Vivo: EST73502 (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test in CD1 male mice.
EST73502 (5 mg/kg; i.p.; twice a day; for 10 days) attenuates partial sciatic nerve ligation (PSNL)-induced mechanical allodynia in male CD1 mice.
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文献和实验EST Databases and Web Tools for EST Projects
This chapter outlines key considerations for constructing and implementing an EST database. Instead of showing the technological details step by step, emphasis is put on the design of an EST database suited to the specific needs of EST
EST Processing: From Trace to Sequence
A common task in EST projects is the conversion of sequence chromatograms originating from gel-based or capillary sequencers into annotated sequence objects. Here we describe the usage of a software pipeline (available from http://www
Phylogenomic Analysis of EST Datasets
to explore phylogenetic relationships and species diversity. The identification of highly diverse sequences specific to an EST-based sequence dataset offers insights into the extent of genetic novelty within that dataset. Sequences that are only shared
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