Squarunkin A hydrochloride

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Squarunkin A hydrochloride

CAS No. : 2253744-55-5

MCE 国际站：Squarunkin A hydrochloride

产品活性：Squarunkin A hydrochloride 是一种有效的选择性 UNC119-内容物 (Cargo) 相互作用抑制剂，抑制 UNC119A 与肉豆蔻酰化的 Src N 末端肽相互作用 (IC₅₀=10 nM)。Squarunkin A hydrochloride 会干扰细胞中 Src 激酶的活化。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：Src

In Vitro: Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM) treatment leads to a concentration-dependent reduction of Src phosphorylation.
Squarunkin A does not target the lipoprotein-binding sites of other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which bind S-prenylated proteins. Squarunkin A binds to UNC119 in cell lysate and interferes with Src activation.

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