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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
5 mg
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LY-311727
CAS No. : 164083-84-5
MCE 国际站：LY-311727
产品活性：LY-311727 是一种分泌型磷脂酶 A2 (sPLA2) 抑制剂 (IC50 <1 μM for group IIA sPLA2)。sPLA2 是一种重要的促炎症酶。
研究领域：Metabolic Enzyme/Protease
作用靶点：Phospholipase
In Vitro: LY-311727 (0.1-10 μM) suppresses the contractile responses induced by human non-pancreatic secretory phospholipase A2 (hnps-PLA2), in a concentration related manner.
LY-311727 nearly abolishes the hnps-PLA2 responses at 1 μM, while it failed to suppress porcine pancreatic PLA2 concentration response curves at the same concentration.
LY-311727 displays 1,500-fold selectivity when assayed against porcine pancreatic s-PLA2.
In Vivo: LY-311727 (3-30 mg/kg; i.v.) dramatically suppresses the circulating enzyme activity in mice with metallothionein promoter-human secretory PLA2 minigene (Mt-sPLA2) transgenic the intravenous (i.v.) administration.
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文献和实验at 37℃ in 5% CO2/95% air for 24h. The medium was aspirated and replaced with medium containing arsenic trioxide (final concentration 0.5μmol/L, 1μmol/L, 2μmol/L, respective ly) as treatment groups and medium with non-arsenic trioxide as controls
mite extract (Dermatophagoides pteronyssinus) Lyophilized 10.000 IU / ampoule. 人抗Haman血小板5B抗原型抗体 人全绒毛膜促性腺激素免疫分析冻干粉 1.88 nmol / ampoule 人绒毛膜促性腺激素α亚单元免疫分析冻干粉 0.84 nmlo / ampoule 人绒毛膜促性腺激素β核心片段免疫分析冻干粉 1.02 nmol / ampoule 人绒毛膜促性腺激素β亚单元免疫分析冻干粉 0.88 nmol
pteronyssinus) Lyophilized 10.000 IU / ampoule. 人抗Haman血小板5B抗原型抗体 人全绒毛膜促性腺激素免疫分析冻干粉 1.88 nmol / ampoule 人绒毛膜促性腺激素α亚单元免疫分析冻干粉 0.84 nmlo / ampoule 人绒毛膜促性腺激素β核心片段免疫分析冻干粉 1.02 nmol / ampoule 人绒毛膜促性腺激素β亚单元免疫分析冻干粉 0.88 nmol / ampoule Nicked HCGβ亚单元(hCG-beta-n)免疫
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