- ￥480 - 3840
- MedChemExpress(MCE)
- 美国
- HY-16772
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Pure form: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥480.0 |
| 规格： | 5 mg | 产品价格： | ￥1200.0 |
| 规格： | 10 mg | 产品价格： | ￥1920.0 |
| 规格： | 25 mg | 产品价格： | ￥3840.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
EPI-743
CAS No. : 1213269-98-7
MCE 国际站：EPI-743
产品活性：EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) 是一种有效的细胞氧化应激保护剂，抑制细胞发生铁死亡 (ferroptosis)，可用于线粒体疾病的研究。EPI-743 是维生素 E 类似物，具有口服活性，可以通过影响细胞内谷胱甘肽的氧化还原状态来防止过量的 ROS 产生。
研究领域：Metabolic Enzyme/Protease | Apoptosis
作用靶点：Mitochondrial Metabolism | Ferroptosis
In Vitro: Ferroptosis is a form of iron- and lipid-dependent regulated cell death associated with glutathione depletion and production of lipid peroxides by lipoxygenase enzymes.
EPI-743 prevents RSL3-induced ferroptosis in PCH6 patient fibroblasts with mean EC50 potency values of 17.3-21.8 nM.
EPI-743 (37, 111, 333 nM; 24 h) exhibits prevention of BODIPY 581/591 C11 lipid oxidation.
EPI-743 (0.1 nM-1 mM; 48 h) potently prevents ferroptosis induced by RSL3 (2 μM), FeC (100 μM), BSO (50 μM).
EPI-743 (1 μM, 3 h) is reduced to EPI-743 hydroquinone (EPI-743-HQ) in PCH6 patient fibroblasts, and EPI-743-HQ (0.1-100 μM; 30 min) inhibits human 15-LO enzyme activity with 20% inhibition at 100 μM, and IC50 is 4.4 μM.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Metabolism/Protease Compound Library | Stem Cell Signaling Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Mitochondria-Targeted Compound Library | Glucose Metabolism Compound Library | Rare Diseases Drug Library | Cuproptosis Compound Library | Cell Death Library | Ferrostatin-1 | Erastin | Cisplatin | Cycloheximide | RSL3 | Acetylcysteine | Sorafenib | ML385 | Necrostatin-1 | Rotenone | SP600125 | MitoSOX Red | CCCP | Rosiglitazone | Liproxstatin-1 | FCCP | Curcumin | Mito-TEMPO | Simvastatin | Hemin | TBHQ | Lapatinib | Roxadustat | L-Glutathione reduced | Trolox | Lovastatin | Sulfasalazine | NADPH tetrasodium salt | U-73122 | UK-5099
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验在发明阿司匹林 11 天后，他又发明了海洛因：史上最矛盾的科学家
待自己的作品？卡拉什尼科夫的回应很简单：杀人的不是枪，是扣动扳机的人。封面来源：图虫创意参考资料1.https://baike.baidu.com/tashuo/browse/content?id=ced913fd24cbe616c93805ce&lemmaId=118238&fromLemmaModule=pcBottom2.https://baike.baidu.com/item/%E9%98%BF%E5%8F%B8%E5%8C%B9%E6%9E%97/157772.https://digital
Oxford Biomedical Research的氧化应激及慢性炎症生物标志物检测
). （5）Wang, et al., Immunological characterization of urinary 8-epi-prostaglandin F2a excretion in man. J. Pharm. Exp. Ther. 275:94-100 (1995). （6）Morrow, J., Zackert, W., Yang, J., Kuhrts, E., Callewaert, D., Taber, D., Oates, J., Roberts, J
, Germany) according to the manufacturer's instruction with minor modifications [11]. Purity was routinely >98% as assessed by fluorescence analysis.Cell stimulationPurified CD19+ B cells were cultured in Iscove Dulbecco's Modified Medium (IDMM; Bio
技术资料暂无技术资料 索取技术资料
