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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
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10 mM * 1 mL/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4950.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥4500.0 |
| 规格： | 10 mg | 产品价格： | ￥8000.0 |
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POMHEX
CAS No. : 2004714-34-3
MCE 国际站：POMHEX
产品活性：POMHEX 是一个消旋混合物，是具有细胞渗透性的 HEX 的 POM 前体活性分子，是 ENO2 的特异性抑制剂。POMHEX 对 ENO1 缺失的细胞表现出低纳摩尔级别活性，并对 ENO1 缺失的肿瘤模型表现出良好的抗癌效果。POMHEX 是有效的糖酵解抑制剂。
研究领域：Metabolic Enzyme/Protease | Apoptosis
In Vitro: POMHEX (78 nM, 8h) minimally impacts ENO1-WT glioma cells but profoundly affected ENO1-deleted cells.
?POMHEX (0-720 nM) selectively induces energy stress, inhibits proliferation and triggers apoptosis in ENO1-deleted glioma cells.
In Vivo: POMHEX (i.v., ip) injections are consistently tolerated without haemolytic anaemia at doses of up to 10 mg per kg (body weight) per day. POMHEX (i.v., 35 mg/kg) results in lethargy that prompted veterinarians to perform euthanasia.
?POMHEX is rapidly hydrolysed to HemiPOMHEX in mouse plasma ex vivo, with a half-life of approximately 30 s, the half-life in human blood ex vivo was about 9min.
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