MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:MCP-2/CCL8 Protein, Mouse (HEK293, His)
MCP-2/CCL8 Protein, Mouse (HEK293, His) 是一种 CC 趋化因子,可以与 CCR1、CCR2B、CCR3 和 CCR5 相互作用,介导宿主炎症免疫反应、肿瘤发生以及抗病毒感染。MCP-2/CCL8 Protein, Mouse (HEK293, His) 是一种由 HEK293 表达的重组小鼠 MCP-2/CCL8 (E20-P97) 蛋白,并带有 his 标签。
Synonyms: rMuCCL8, His; C-C motif chemokine 8; Ccl8; Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; MCP-2; Small-inducible cytokine A8; Mcp2; Scya8
Species: Mouse
Source: HEK293
研究背景:CCL8, also known as monocyte chemotactic protein 2 ( MCP2), is a small cell factor belonging to the CC chemokine family. First identified in human osteosarcoma cells, it is a protein encoded by the CCL8 gene located on human chromosome 17. CCL8 is mainly expressed in small intestine and peripheral blood cells. CCL8 can bind to several different chemokine cell surface receptors, such as CCR1, CCR2B, CCR3 and CCR5. CCL8 can act as a chemoattractant, attracting chemokines such as monocytes, lymphocytes, basophils and eosinophils to mediate inflammatory host responses. On the one hand, CCL8 contributes to the spread of breast cancer and promotes the migration and invasion of esophageal squamous cell carcinoma. On the other hand, it has also been reported that CCL8 inhibits cervical cancer tumor growth and exhibits anti-tumor metastatic effects in melanoma. cCL8 significantly activates ERK1/2 phosphorylation in glioblastoma cells and significantly reduces the invasiveness of glioma cells by neutralizing antibody blockade of tama-secreted CCL8. At the same time, CCL8 can act as a potent HIV1 inhibitor with high affinity for the receptor CCR5, which is one of the major co-receptors for HIV1.
蛋白编号:Q9Z121 (E20-P97)
基因 ID:20307
产品分类:细胞因子和生长因子 | 趋化因子 | CC 趋化因子 | 趋化因子 CCL8
Categories:Cytokines and Growth Factors | Chemokine & Receptors | CC Chemokines | MCP-2 Protein/CCL8
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪前沿的制药及生命科学研究进展,为您提供全球前沿的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。