CCL27 蛋白, Human

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CCL27 Protein, Human

MCE 国际站：CCL27 Protein, Human

CCL27 Protein, Human 是一种 CC 趋化因子，可以与趋化因子受体 CCR10 结合作用，吸引皮肤相关记忆 T 淋巴细胞，介导淋巴细胞归巢至皮肤部位，在皮肤炎症中起着关键作用。CCL27 Protein, Human 一种由 E. coli 表达的重组人 CCL27(F25-G112) 蛋白。

Synonyms: rHuCCL27; C-C Motif Chemokine 27; CC Chemokine ILC; Cutaneous T-Cell-Attracting Chemokine; CTACK; Eskine; IL-11 R-Alpha-Locus Chemokine; Skinkine; Small-Inducible Cytokine A27; CCL27; ILC; SCYA27

Species: Human

Source: E. coli

研究背景：CCL27, also known as skin T-cell attracting chemokine (CTACK), is a CC chemokine located on chromosome 9 in the human genome.CCL27 is abundantly expressed in basal keratin-forming cells. Expression is lowest in basal suprabasal keratin-forming cells of normal skin; however, they exhibit stronger CCL27 expression in lesions of human AD, contact dermatitis, and psoriasis. In addition, CCL27 is present in the dermal extracellular matrix (ECM) of the epidermal plexus, fibroblasts and endothelial cells, especially in inflamed skin . By binding to chemokine receptor 10 (CCR10), CCL27 regulates inflammation by promoting the migration of lymphocytes into the skin. CCL27 contributes to tissue-restricted leukocyte trafficking by exhibiting high receptor and tissue specificity, and induces inflammation by promoting lymphocyte migration into the skin.CCL27 induces expression of cultured normal human keratinocytes (NHEK) via the pro-inflammatory factors TNFα and IL-1.

蛋白编号：Q9Y4X3 (F25-G112)

基因 ID：10850

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL27

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  CCL27

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