- ￥190 - 980
- MedChemExpress(MCE)
- 美国
- HY-N0375
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
相关阅读
源叶生物 十万种现货试剂速发，品质稳、品类全，实验不再等！Takara 秋促来袭，提取+反转录+定量套装仅 1200 元abinScience 体内级抗体 全年锁价 低至 ￥1200阿拉丁 22万+ 科研级产品现货速发，品质严控、科研无忧- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥209.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥190.0 |
| 规格： | 25 mg | 产品价格： | ￥380.0 |
| 规格： | 50 mg | 产品价格： | ￥610.0 |
| 规格： | 100 mg | 产品价格： | ￥980.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
18α-Glycyrrhetinic acid
CAS No. : 1449-05-4
MCE 国际站：18α-Glycyrrhetinic acid
产品活性：18α-Glycyrrhetinic acid，一种饮食衍生的化合物，是 NF-kB 的抑制剂和蛋白酶体 (proteasome) 的激活剂，在多细胞生物中起到促进长寿和抗聚集因子的作用。18α-Glycyrrhetinic acid 诱导细胞凋亡。
研究领域：Metabolic Enzyme/Protease | NF-κB | Apoptosis
作用靶点：Proteasome | NF-κB | Apoptosis
In Vitro: 18α-Glycyrrhetinic acid (18a-GA) markedly reduces LX-2 cell numbers by 14.8% and 31.2% after 48 h and 72 h of treatment, respectively (P< 0.05). 18α-Glycyrrhetinic acid also significantly increases the percentage of LX-2 cells in phase G0/G1 and decreases it in phase S after treated for 48 h and 72 h compare with the control group. 18α-Glycyrrhetinic acid increases apoptosis to 6.8% at 48 h, compare with control (2.5%), and at 72 h the percentages of apoptotic cells in control and the treatment groups are 3.1% and 15.6%, respectively, in LX-2 cells (P<0.01). Furthermore, 18α-Glycyrrhetinic acid induces expression of PPAR-γ and alters some cell cycle and apoptosis-related proteins. 18α-Glycyrrhetinic acid also inhibits NF-κB DNA-binding activity.
In Vivo: 18α-Glycyrrhetinic acid (18α-GA) treatment significantly enhances life span of C. elegans strains with the most effective concentration being 20 μg/mL. Results reveal a significant delay of paralysis upon 18α-Glycyrrhetinic acid treatment. 18α-Glycyrrhetinic acid treatment also confers a significant reduction of Aβ deposits.
相关产品：Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Ubiquitination Compound Library | NMPA-Approved Drug Library | Medicine Food Homology Compound Library | Terpenoids Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Food-Sourced Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Off-patent Drug Library | Mitochondrial Toxicity Compound Library | Cell Death Library | FDA-Approved Traditional Chinese Medicine Active Compound Library | MG-132 | Phorbol 12-myristate 13-acetate | Doxorubicin hydrochloride | Bafilomycin A1 | LY294002 | Tamoxifen | Paclitaxel | Y-27632 | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | SB-431542 | Actinomycin D | Deferoxamine mesylate | Bortezomib | 5-Fluorouracil | Trametinib | Sorafenib | Oxaliplatin | Gemcitabine | Temozolomide | Rotenone | Mdivi-1 | Elesclomol | Ruxolitinib | Decitabine | SP600125 | MK-2206 dihydrochloride | Etoposide
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验胰腺是分泌血糖稳态激素的重要器官，是人体内控制血糖动态平衡的中心。胰腺的内分泌功能主要是由胰岛来完成的，每个胰岛都是一个复杂的微器官，由上千个分泌细胞组成。经典的胰岛内分泌细胞包括 α 细胞、β 细胞、δ 细胞、ε 细胞和 PP 细胞，分别主要产生胰高血糖素（glucagon）、胰岛素、生长抑素（SS）、生长素释放肽及胰多肽，其在成体胰岛内分别约占 20%、75%、3%～5%、1% 和＜2%【1】。 胰岛移植为 I 型和晚期 II 型糖尿病患者提供了卓越的长期血糖控制，但是成体胰岛组织的可
玉米Proline responding 1(pro1)突变在蛋白合成和细胞周期调控中起到关键作用
蛋白合成的普遍下降。Figure 4Uncharged tRNApro Accumulation Caused by Proline DeficiencyTriggers the Phosphorylation of eIF2α(A) Free proline content analysis of 12 DAP (I), 18 DAP (II), and 24 DAP (III) endosperm from wild type and pro1-ref.For each sample
功能障碍有关 2024 年 2 月 9 日，南京大学医学院附属鼓楼医院心脏科的研究团队在 Cardiovascular Diabetology（影响因子：9.6）期刊发表了题为：Circulating exosomal mir-16-2-3p is associated with coronary microvascular dysfunction in diabetes through regulating the fatty acid degradation of endothelial cells 的研究
技术资料暂无技术资料 索取技术资料
