- ￥453
- Sigma-Aldrich
- 进口
- 215902-25G
- 2026年01月21日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温
- 保质期：
根据瓶身LOT号查询
- 英文名：
Lead(II) acetate trihydrate
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
6080-56-4
- 规格：
25G
属性
等级
ACS reagent
质量水平
200
检测方案
≥99%
99.0-103.0% (ACS specification)
形式
solid
反应适用性
reagent type: catalyst
core: lead
mp
75 °C (dec.) (lit.)
痕量阴离子
NO3- and NO2-: ≤0.005%
chloride (Cl-): ≤5 ppm
痕量阳离子
Ca: ≤0.005%
Cu: ≤0.002%
Fe: ≤0.001%
K: ≤0.005%
Na: ≤0.01%
SMILES字符串
O.O.O.CC(=O)O[PbH2]OC(C)=O
InChI
1S/2C2H4O2.3H2O.Pb/c2*1-2(3)4;;;;/h2*1H3,(H,3,4);3*1H2;/q;;;;;+2/p-2
InChI key
MCEUZMYFCCOOQO-UHFFFAOYSA-L
应用
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验APE1/Ref-1 prevents oxidative inactivation of ERK for G1-to-S progression following lead acetate exposure.
Apurinic/apyrimidinic endonuclease 1 (APE1)/redox effector factor-1 is a multifunctional enzyme involved in DNA base excision repair and protein redox regulation. Previously, we have showed that lead acetate (Pb) elicits EGFR activation to initiate the SFK/PKCα/Ras/Raf-1/MKK1/2/ERK signaling cascade functioning against genotoxicity. Here, we explore whether APE1 and reactive oxygen species (ROS) affect ERK signaling and cell cycle progression following Pb exposure. We found that Pb induced APE1 expression and ROS generation in CL3 human lung cancer cells. The Pb-elicited ROS levels and cytotoxicity were further enhanced by introducing small interfering RNA specific for APE1 (siAPE1). E3330, an inhibitor of APE1 redox activity, also augmented the ROS levels and cytotoxicity in Pb-treated cells. Intriguingly, the capability of Pb to activate ERK was abolished under siAPE1 or E3330 co-treatments; conversely, forced expression of APE1 up-regulated the ERK activation by Pb or serum in both Cys65-redox activity dependent and independent manners. Moreover, APE1 formed complex with ERK2, and its redox activity could rescue ERK oxidative inactivation. APE1 redox activity also facilitated the Cyclin D1 expression and G1-to-S progression following Pb exposure. In summary, the results indicate that APE1 is a direct redox regulator of ERK for maintaining the kinase activity to promote cell proliferation.
网络 中西医结合诊治 慢性胃炎 56例分析 我科自1994年2月以来，采用中西医结合的方法治疗 慢性胃炎 56例，效果显著，报告如下。 1 对象和方法 1.1 对象 本组病例男51例，女5例，年龄17岁～56岁，病程均在5月～12a，其中浅表
醛0.5ml，加醋酸50ml使溶解，加硫酸1ml，摇匀，即得。 本液应临用新制。 32.钨酸钠试液 取钨酸钠25g，加水72ml溶解后，加磷酸2ml，摇匀，即得。 33.品红亚硫酸试液 取碱式品红0.2g，加热水100ml溶解后,放冷加亚硫酸钠溶液(1→10)20ml、盐酸2ml，用水稀释至200ml，加活性炭0.1g，搅拌并迅速滤过，放置1小时以上，即得。 本液应临用新制。 34.香草醛试液 取香草醛0.1g，加盐酸10ml使溶解，即得。 香草醛硫酸试液 取香草醛0.2g，加硫酸10
氟蓝0.19g，加氢氧化钠溶液(1.2→100)12.5ml，加水800ml与醋酸钠结晶0.25g，用稀盐酸调节pH值约为5.4，用水稀释至1000ml，摇匀，即得。 茜素锆试液 取硝酸锆5mg，加水5ml与盐酸1ml；另取茜素磺酸钠1mg，加水5ml,将两液混合，即得。 草酸试液 取草酸6.3g，加水使溶解成100ml，即得。 草酸铵试液 取草酸铵3.5g，加水使溶解成100ml，即得。 枸橼酸醋酐试液 取枸橼酸2g，加醋酐100ml使溶解，即得。 品红亚硫酸
技术资料暂无技术资料 索取技术资料
