阻击疫情|新冠(SARS-CoV-2)相关产品 (蛋白/抗体

什么是冠状病毒？

冠状病毒属于套式病毒目、冠状病毒科、冠状病毒属，是一类具有囊膜、基因组为线性单股正链的RNA病毒，是自然界广泛存在的一大类病毒。它不仅是普通感冒的主要病原体之一，更是几次严重疫情的罪魁祸首。2003年肆虐的严重急性呼吸综合征冠状病毒，以及前几年影响沙特阿拉伯、韩国等地的中东呼吸综合征冠状病毒，在分类上都是冠状病毒科冠状病毒属中的病毒。如Figure 1所示，冠状病毒呈球形，膜上有冠状突起，直径为75-160 nm，病毒基因组为连续的线性单链RNA，分子量通常为（5.5-6.1）x10⁶。

Figure 1. The Typical Structure of Coronavirus

冠状病毒基因组依次编码刺突蛋白（S）、包膜蛋白、膜蛋白和核蛋白。其中，刺突蛋白是冠状病毒最重要的表面膜蛋白。
 

什么是新型冠状病毒？

新型冠状病毒是2019年在人体中发现的冠状病毒新毒株，并于2020年1月12日被世界卫生组织命名为SARS-CoV-2。它与2003年的SARS冠状病毒（SARS CoV）均属于冠状病毒的β属。SARS-CoV-2与2003年"非典"SARS CoV比对，有约70%序列相似性，与MERS CoV有40%的序列相似性。

华美生物密切关注SARS-CoV-2的发展趋势，获取病毒基因序列后，我司迅速开发生产了SARS-CoV-2相关蛋白和抗体产品。产品涵盖了大肠杆菌、酵母、杆状病毒和哺乳动物细胞来源的Spike蛋白（S）和N蛋白（N），以满足科研、检测和制备SARS-CoV-2抗体需求。您可以单击以下按钮查看与SARS-CoV-2相关的完整产品。

SARS-CoV-2是如何传播？

相关研究表明，新型冠状病毒可通过与眼、口和鼻粘膜中的ACE2相互作用进入人体。目前该病毒正在中国许多地方及其他国家中人与人之间传播。 1月30日，疾病控制与预防中心（CDC）确定了美国首例人际传播病例。目前SARS-CoV-2可能传播的途径包括：

• 呼吸道飞沫传播：是新型冠状病毒主要的传播途径，同时也可以通过接触传播。手触摸的物品被含病毒的飞沫污染，病毒可能会经手进入口腔、鼻腔、眼睛等粘膜；
• 空气传播：病毒携带者或感染者的喷嚏和咳嗽；
• 消化系统：也就是常说的粪口传播，部分感染者的粪便中已发现病毒核酸。

 

感染SARS-CoV-2后症状有哪些？

如Figure 2所示，感染新冠状病毒后的主要症状包括：

• 以发热、乏力和干咳为主要表现；
• 鼻塞、流涕等上呼吸道症状少见；
• 约半数患者多在一周后出现呼吸困难，严重者快速进展为急性呼吸窘迫综合症、脓毒症休克、难以纠正的代谢性酸中毒和凝血功能障碍。

值得注意的是重症、危重症患者病理过程中可为中低热，甚至无明显发热，部分患者起病症状轻微，可无发热，多在一周后恢复，多数患者预后良好，少数患者病情危重，甚至死亡。

Figure 2. The Sympotoms of SARS-CoV-2
 

SARS-CoV-2来源于何处？

目前，SARS-CoV-2的来源尚不清楚。有专家猜测，这次可能仍然和其他冠状病毒一样均来源于野生动物。冠状病毒通常来源于动物，如骆驼、小鸟和蝙蝠，通常不传染给人类。但是有时候，冠状病毒会发生突变，然后从动物传播给人类，进而发展成人传人，比如2003年SARS流行病。中国国家卫生委员会证实，已有15名医护人员被感染，表明该病毒可以在人与人之间传播。

读到这里，您可能会感到困惑，我应该担心宠物（例如狗和猫）携带SARS-CoV-2吗？这个目前并没有证据显示猫狗等宠物会感染、传播新型冠状病毒。但从卫生角度考虑，与宠物接触后，应用肥皂和水洗手。

 

 

华美生物已经建立新冠病毒突变株抗原库，助力新型冠状病毒研究，高质量SARS-CoV-2相关科研产品持续更新中，包括新冠病毒相关ELISA试剂盒、S蛋白/抗体、N蛋白/抗体、RBD纳米抗体、Spike RBD抗体对、八大突变体蛋白、新冠非结构蛋白、新冠病毒-宿主互作蛋白等相关产品！
 

 

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SARS-CoV-2 蛋白产品

Target Name	Product Name	Code	Species	Source	Tag Info
E & M	Recombinant Severe acute respiratory syndrome coronavirus 2 Envelope small membrane protein & Membrane protein(E & M),partial	CSB-EP3402GND	SARS-CoV-2	E.coli	N-terminal 6xHis-SUMO-tagged
N	Recombinant Human Novel Coronavirus Nucleoprotein(N)	CSB-EP3325GMY	SARS-CoV-2	E.coli	N-terminal 6xHis-tagged
N	Recombinant Human Novel Coronavirus Nucleoprotein(N)	CSB-YP3325GMY	SARS-CoV-2	Yeast	N-terminal 6xHis-PDI-tagged
N	Recombinant Human Novel Coronavirus Nucleoprotein(N)	CSB-MP3325GMY	SARS-CoV-2	Mammalian cell	Tag-Free
N	Recombinant Human Novel Coronavirus Nucleoprotein(N)	CSB-YP3325GMYa4	SARS-CoV-2	Yeast	N-terminal 6xHis-sumostar-tagged
N	Recombinant Human Novel Coronavirus Nucleoprotein(N),partial	CSB-EP3325GMY1	SARS-CoV-2	E.coli	C-terminal 10xHis-tagged
N	Recombinant Human Novel Coronavirus Nucleoprotein(N),Biotinylated	CSB-EP3325GMY-B	SARS-CoV-2	E.coli	N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged
NSP3	Recombinant Severe acute respiratory syndrome coronavirus 2 Non-structural protein 3(nsp3),partial	CSB-EP3398GND	SARS-CoV-2	E.coli	N-terminal 10xHis-tagged
NSP5	Recombinant Severe acute respiratory syndrome coronavirus 2 3C-like proteinase(NSP5)	CSB-EP3389GND	SARS-CoV-2	E.coli	N-terminal 10xHis-tagged
Nsp9	Recombinant Severe acute respiratory syndrome coronavirus 2 Non-structural protein 9(nsp9)	CSB-MP3388GND	SARS-CoV-2	Mammalian cell	C-terminal hFC-Flag-tagged
Nsp9	Recombinant Severe acute respiratory syndrome coronavirus 2 Non-structural protein 9(nsp9)	CSB-EP3388GND	SARS-CoV-2	E.coli	C-terminal 10xHis-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S), partial	CSB-YP3324GMY2	SARS-CoV-2	Yeast	N-terminal 6xHis-PDI-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S), partial	CSB-MP3324GMY1	SARS-CoV-2	Mammalian cell	C-terminal 6xHis-mFc-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S), partial	CSB-MP3324GMY1b1	SARS-CoV-2	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S), partial	CSB-YP3324GMY1	SARS-CoV-2	Yeast	N-terminal 6xHis-sumostar-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S) (K417N),partial	CSB-MP3324GMY1(M7)	SARS-CoV-2	Mammalian cell	C-terminal 10xHis-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S) (K417N),partial	CSB-MP3324GMY1(M7)h8	SARS-CoV-2	Mammalian cell	C-terminal mFC-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S) (E484K),partial	CSB-MP3324GMY1(M8)	SARS-CoV-2	Mammalian cell	C-terminal 10xHis-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S) (E484K),partial	CSB-MP3324GMY1(M8)h8	SARS-CoV-2	Mammalian cell	C-terminal mFC-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S) (V367F), partial	CSB-MP3324GMY1(M1)	SARS-CoV-2	Mammalian cell	C-terminal 10xHis-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S) (W436R), partial	CSB-MP3324GMY1(M2)	SARS-CoV-2	Mammalian cell	C-terminal 10xHis-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S) (G476S), partial	CSB-MP3324GMY1(M4)	SARS-CoV-2	Mammalian cell	C-terminal 10xHis-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S) (N501Y), partial	CSB-MP3324GMY1(M6)	SARS-CoV-2	Mammalian cell	C-terminal 10xHis-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S) (V483A), partial	CSB-MP3324GMY1(M5)	SARS-CoV-2	Mammalian cell	C-terminal 10xHis-tagged
S (RBD)	Recombinant Human Novel Coronavirus Spike glycoprotein(S), partial,Biotinylated	CSB-MP3324GMY1-B	SARS-CoV-2	Mammalian cell	C-terminal mFc-Avi-tagged
S (S1)	Recombinant Human Novel Coronavirus Spike glycoprotein(S), partial	CSB-YP3324GMYa4	SARS-CoV-2	Yeast	N-terminal 6xHis-sumostar-tagged
S (S1)	Recombinant Human Novel Coronavirus Spike glycoprotein(S), partial	CSB-MP3324GMY	SARS-CoV-2	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Flag-tagged
S (S1)	Recombinant Human Novel Coronavirus Spike glycoprotein(S) (D614G), partial	CSB-MP3324GMY(M1)	SARS-CoV-2	Mammalian cell	C-terminal 10xHis-tagged
S (S1)	Recombinant Human Novel Coronavirus Spike glycoprotein(S)(N501Y,P681H), partial	CSB-MP3324GMY(M2)	SARS-CoV-2	Mammalian cell	C-terminal 10xHis-tagged

SARS-CoV-2 抗体产品

Product Name	Code	Reactivity Species	Tested Applications
N Antibody	CSB-RA33255A0GMY	SARS-CoV-2	ELISA, GICA
N Antibody	CSB-RA33255A1GMY	SARS-CoV-2	ELISA, WB, GICA
N Antibody	CSB-RA33255A2GMY	SARS-CoV-2	ELISA
N Antibody, Biotin conjugated	CSB-RA33255D1GMY	SARS-CoV-2	ELISA
N Antibody, FITC conjugated	CSB-RA33255C1GMY	SARS-CoV-2	ELISA
N Antibody, HRP conjugated	CSB-RA33255B1GMY	SARS-CoV-2	ELISA
S Antibody	CSB-RA33245A0GMY	SARS-CoV-2	ELISA, GICA
S Antibody	CSB-RA33245A1GMY	SARS-CoV-2	ELISA, GICA, Neutralising
S Antibody, Biotin conjugated	CSB-RA33245D1GMY	SARS-CoV-2	ELISA
S Antibody, FITC conjugated	CSB-RA33245C1GMY	SARS-CoV-2	ELISA
S Antibody, HRP conjugated	CSB-RA33245B1GMY	SARS-CoV-2	ELISA
SARS-CoV-2 RBD Nanobody	CSB-RA33245A2GMY	SARS-CoV-2	ELISA, GICA, Neutralising
SARS-CoV-2 RBD Nanobody, Biotin conjugated	CSB-RA33245D2GMY	SARS-CoV-2	ELISA
SARS-CoV-2 RBD Nanobody, FITC conjugated	CSB-RA33245C2GMY	SARS-CoV-2	ELISA
SARS-CoV-2 RBD Nanobody, HRP conjugated	CSB-RA33245B2GMY	SARS-CoV-2	ELISA
SARS-CoV-2 Spike RBD Antibody Pair 1	CSB-EAP33245	SARS-CoV-2	S-ELISA
SARS-CoV-2 N Antibody Pair 1	CSB-EAP33255A1	SARS-CoV-2	S-ELISA
SARS-CoV-2 N Antibody Pair 2	CSB-EAP33255A2	SARS-CoV-2	S-ELISA
SARS-CoV-2 N Antibody Pair 3	CSB-EAP33255A3	SARS-CoV-2	S-ELISA
SARS-CoV-2 N Antibody Pair 4	CSB-EAP33255A4	SARS-CoV-2	S-ELISA

SARS-CoV-2 免疫抗体产品

Product Name	Code	Tested Applications	Raised in
S Monoclonal Antibody	CSB-MA33245A0m	GICA	Mouse
S Monoclonal Antibody	CSB-MA33245A1m	GICA	Mouse
S Monoclonal Antibody	CSB-MA33245A2m	GICA	Mouse
S Antibody	CSB-PA33245YA01GMY	GICA	Rabbit
S Antibody	CSB-PA33245YA11GMY	GICA	Rabbit
N Antibody	CSB-PA33254A0Rb	GICA	Rabbit
N Antibody	CSB-MA33255A0m	GICA	Mouse
N Antibody	CSB-MA33255A1m	GICA	Mouse
N Antibody	CSB-MA33255A2m	GICA	Mouse

SARS-CoV-2 试剂盒产品

Product Name	Code	Sample Types	Assay Principle
SARS-CoV-2 N ELISA Kit	CSB-EL33251	serum, plasma, swabs	Quantitative
Human SARS-CoV-2 S RBD Ab (IgG) ELISA Kit	CSB-EL33241HU	serum, plasma	Qualitative
Human SARS-CoV-2 S RBD Ab (IgM) ELISA Kit	CSB-EL33242HU	serum, plasma	Qualitative
Human SARS-CoV-2 Neutralizing Antibody ELISA Kit	CSB-EL33243HU	serum, plasma	Qualitative
Human SARS-CoV-2 N Ab (IgG) ELISA Kit	CSB-EL3325HU	serum, plasma	Qualitative
Human SARS-CoV-2 N/S1 Ab (IgG) ELISA Kit	CSB-EL3326HU	serum, plasma	Qualitative
SARS-CoV-2 S1 RBD ELISA Kit	CSB-EL33244	serum, plasma, swabs	Quantitative

冠状病毒相关产品

蛋白相关产品
 

Target Name	Product Name	Code	Species	Source	Tag Info
HE	Recombinant Bovine coronavirus Hemagglutinin-esterase(HE)	CSB-YP323648BJK	BCoV	Yeast	N-terminal 6xHis-tagged
N	Recombinant Bovine coronavirus Nucleoprotein(N)	CSB-EP320768BJK	BCoV	E.coli	N-terminal 6xHis-tagged
Orf1ab	Recombinant Middle East respiratory syndrome-related coronavirus Orf1ab, partial	CSB-EP2883GJE	MERS-CoV	E.coli	Tag-Free
S	Recombinant Human coronavirus OC43 Spike glycoprotein(S), partial	CSB-EP336163HIY	HCoV-OC43	E.coli	N-terminal 6xHis-SUMO-tagged
S	Recombinant Human coronavirus OC43 Spike glycoprotein(S), partial	CSB-YP336163HIY	HCoV-OC43	Yeast	N-terminal 6xHis-tagged
S	Recombinant Bovine coronavirus Spike glycoprotein(S), partial	CSB-EP333052BJO	BCoV	E.coli	N-terminal 6xHis-tagged
S	Recombinant Bovine coronavirus Spike glycoprotein(S), partial	CSB-EP322803BJK	BCoV	E.coli	N-terminal 10xHis-tagged
SARS-COV-RBD	Recombinant Human SARS coronavirus Spike glycoprotein(S) ,partial	CSB-MP348663HQE	SARS-CoV	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged

抗体相关产品

Product Name	Code	Species Reactivity	Tested Applications
S Antibody	CSB-PA333052LA01BJO	Bovine coronavirus	ELISA
S Antibody	CSB-PA322803LA01BJK	Bovine coronavirus	ELISA, WB
S Antibody	CSB-PA336163EA01HIY	Human coronavirus OC43	ELISA

冠状病毒与宿主互作靶点产品

蛋白产品

Target Name	Product Name	Code	Species	Source	Tag Info
AXL	Recombinant Human Tyrosine-protein kinase receptor UFO(AXL),partial	CSB-MP326981HU	Human	Mammalian cell	C-terminal 10xHis-tagged
AXL	Recombinant Human Tyrosine-protein kinase receptor UFO(AXL),partial	CSB-MP326981HUd9	Human	Mammalian cell	C-terminal hFC-tagged
ACE2	Recombinant Human Angiotensin-converting enzyme 2(ACE2),partial(Active)	CSB-AP005671HU	Human	Mammalian cell	C-terminal 6xHis-tagged
ACE2	Recombinant Human Angiotensin-converting enzyme 2(ACE2),partial	CSB-MP866317HU	Human	Mammalian cell	C-terminal hFc-tagged
CD147	Recombinant Human Basigin(BSG),partial	CSB-RP117574h	Human	E.coli	N-terminal 6xHis-tagged
CD147	Recombinant Human Basigin(BSG),partial	CSB-MP002831HU	Human	Mammalian cell	C-terminal FC-tagged
CD147	Recombinant Human Basigin(BSG),partial	CSB-MP002831HUf3	Human	Mammalian cell	C-terminal 6xHis-Myc-tagged
CTSB	Recombinant Human Cathepsin B(CTSB),partial (Active)	CSB-AP005381HU	Human	Mammalian cell	C-terminal 6xHis-tagged
CTSB	Recombinant Human Cathepsin B(CTSB),partial	CSB-EP006185HU1	Human	E.coli	N-terminal GST-tagged
DPP4	Recombinant Human Dipeptidyl peptidase 4(DPP4)	CSB-CF007139HU	Human	in vitro E.coli expression system	N-terminal 10xHis-tagged
NUP98	Recombinant Human Nuclear pore complex protein Nup98-Nup96(NUP98) ,partial	CSB-MP016209HU	Human	Mammalian cell	C-terminal hFC-tagged
TMPRSS2	Recombinant Human Transmembrane protease serine 2(TMPRSS2),partial	CSB-EP023924HU	Human	E.coli	N-terminal 6xHis-tagged
TMPRSS2	Recombinant Human Transmembrane protease serine 2(TMPRSS2),partial	CSB-YP023924HU	Human	Yeast	N-terminal 6xHis-tagged

抗体产品

Product Name	Code	Species Reactivity	Tested Applications
ACE2 Antibody	CSB-PA866317LA01HU	Human	ELISA, IHC, IF
ACE2 Antibody	CSB-PA001150GA01HU	Human, Mouse, Rat	ELISA,WB
APN Antibody	CSB-PA001827LA01HU	Human, Mouse	ELISA, WB, IHC, IF
APN Antibody	CSB-PA001827GA01HU	Human,Mouse,Rat	ELISA,WB
CD147 antibody	CSB-PA11759A0Rb	Human	ELISA, WB, IHC
CTSB Antibody	CSB-PA06974A0Rb	Human, Mouse	ELISA, WB, IHC, IF
DPP4 Antibody	CSB-PA06229A0Rb	Human, Rat	ELISA, WB, IHC, IF
DPP4 Antibody	CSB-PA007139GA01HU	Human,Mouse,Rat	ELISA,WB,IHC
TMPRSS2 Antibody	CSB-PA971239	Human	ELISA,WB

ELISA Kit 产品

Product Name	Code	Sample Types	Detection Range
Human ACE2 ELISA Kit	CSB-E04489h	serum, plasma, cell culture supernates	0.156 ng/mL-10 ng/mL
Human APN ELISA kit	CSB-EL001827HU	serum, plasma, tissue homogenates	31.25 pg/mL-2000 pg/mL
Human CD147 ELISA Kit	CSB-E12994h	serum, plasma	12.5 pg/mL-800 pg/mL
Human CTSB ELISA kit	CSB-E13450h	serum, plasma, tissue homogenates	0.312 ng/mL-20 ng/mL

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