Recombinant Human Kallikrein-1

产品名称：【KLK1】重组人激肽释放酶-1-Recombinant Human Kallikrein-1

产品货号：enz-293-E

产品规格：1

应用类型：人激肽释放酶-1重组蛋白是在毕赤酵母中重组表达的，是一条单链、糖基化的多肽链，包含有238个氨基酸，分子量为28-32kDa.该人激肽释放酶-1重组蛋白终由标准的色谱技术纯化出.

保存建议：【KLK1】重组人激肽释放酶-1-Recombinant Human Kallikrein-1人激肽释放酶-1（KLK1）溶液可以在4℃冷藏保存3周；如果想延长保存时间，建议分装后置于-18℃冻存.请避免反复冻融.

背景资料：Kallikreins are serine protease enzymes having various physiological functions.Kallikreins are implicated in carcinogenesis and have potenital as novel cancer disease biomarkers. KLK1 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK1 is functionally conserved in its ability to release the vasoactive peptide， Lys-bradykinin， from low molecular weight kininogen.Human Kallikrein-1， also called as Kallidinogenase， Kininogenase or Kininogenin， is an active protein enzyme present in saliva， pancreatic juices， and urine that catalyzes the proteolysis of bradykininogen to bradykinin.Kallikrein-1， which derived from human or porcine， have been used as drugs for a long time， they are mainly used in the treatment f light to medium hypertension and occlusion of cerebral and surrounding blood vessels.KLK1 demonstrates both trypsin- and chymotrypsin-like selectivities with Tyr/Arg preferred at site P1， Ser/Arg strongly preferred at P1’， and Phe/Leu at P2.rs5517 in the KLK1 gene is considerably connected with hypertension in a Chinese Han population. KLK1 is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins. The K allele of KLK1 promoter and TT genotype of TGF-beta1 are a genetic KLK1 -130 GN and -128 G-C， and the defenselessness factor contributing to progressive renal descent in Taiwanese primary vesicoureteric reflux children.Induction of KLK1 in carotid arteriosclerosis doesn’t lead to kallikrein-kinins pathway activation. Transgenic rats expressing KLK1 have impaired renal response to acute volume expansion Endothelial cells synthesize and release active form of KLK1on the surface which is important function in maintenance of circulation homeostasis.KLK1 participates in epidermal desquamation through cleavage of desmoglein 1 and regulation by lympho-epithelial Kazal-type-related inhibitor（LEKTI).

点击：【KLK1】重组人激肽释放酶-1-Recombinant Human Kallikrein-1查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询ProSpec中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品网站。

ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。

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关键词：Recombinant Human Kallikrein-1，【KLK1】重组人激肽释放酶-1，KLK1