- ￥1264
- Sigma-Aldrich
- 进口
- A9731-1G
- 2025年09月04日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
2-8°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
Albumin human
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
70024-90-7
- 规格：
1G
属性
生物来源
human
质量水平
200
重组
expressed in rice
方案
≥96% (SDS-PAGE)
表单
lyophilized powder
分子量
monomer ~67 kDa
技术
cell culture | mammalian: suitable
杂质
≤1 EU/mg protein
UniProt登记号
P02768
储存温度
2-8°C
SMILES字符串
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
基因信息
human ... ALB(213)
应用
生化/生理作用
特点和优势
优势
- 消除了动物来源的添加剂
- 安全且符合监管要求
- 证明在胚胎、间充质、神经、心脏、肝脏、肾脏、角质形成细胞和成纤维干细胞系中可有效增强干细胞的生长
- 维持干细胞处在未分化状态
- 消除了贴壁细胞系培养板的涂层
- 提供性质明确且稳定一致的干细胞培养基
分析说明
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文献和实验High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme.
There are currently few approved effective treatments for SARS-CoV-2, the virus responsible for the COVID-19 pandemic. Nanobodies are 12-15 kDa single-domain antibody fragments that can be delivered by inhalation and are amenable to relatively inexpensive large scale production compared to other biologicals. We have isolated nanobodies that bind to the SARS-CoV-2 spike protein receptor binding domain and block spike protein interaction with the angiotensin converting enzyme 2 (ACE2) with 1-5 nM affinity. The lead nanobody candidate, NIH-CoVnb-112, blocks SARS-CoV-2 spike pseudotyped lentivirus infection of HEK293 cells expressing human ACE2 with an EC50 of 0.3 µg/mL. NIH-CoVnb-112 retains structural integrity and potency after nebulization. Furthermore, NIH-CoVnb-112 blocks interaction between ACE2 and several high affinity variant forms of the spike protein. These nanobodies and their derivatives have therapeutic, preventative, and diagnostic potential.
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