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- Sigma-Aldrich
- 进口
- A9525-1MG
- 2025年07月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
−20°C
- 保质期：
根据瓶身LOT号查询
- 英文名：
Angiotensin II human
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
4474-91-3
- 规格：
1MG
属性
生物来源
synthetic
质量水平
300
方案
≥93% (HPLC)
表单
powder
储存条件
(Keep container tightly closed in a dry and well-ventilated place)
浓度
≤100%
技术
cell culture | mammalian: suitable
杂质
1.2-10.4% acetate
溶解性
water: 25 mg/mL, clear, colorless
UniProt登记号
P01019
储存温度
−20°C
SMILES字符串
[nH]1cncc1C[C@H](NC(=O)C(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)CCCNC(=N)N)C(C)C)Cc4ccc(cc4)O)[C@H](CC)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](Cc3ccccc3)C(=O)O
InChI
1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1
InChI key
CZGUSIXMZVURDU-GYGDIBSWSA-N
基因信息
human ... AGT(183)
Amino Acid Sequence
一般描述
应用
- 人类血管紧张素 II（angII）已用于：
- 研究其对白细胞介素β–介导的胰岛炎症和 β-细胞功能障碍的影响。
- 确定 angII 是否激活心肌中特异性钙调神经磷酸酶依赖性 NFAT（活化 T 细胞核因子）亚型。
- 研究全身输注 angII 对活体肾小球通透性的作用。
- 在 ApoE 敲除小鼠中诱导腹主动脉瘤(AAAs)进行实验研究。
- 研究 AngⅡ 输注对雄性 C57/BL6 小鼠心房支链氨基酸（BCAAs）分解代谢的影响。
- 探究 AngⅡ 对正常大鼠血浆甘油三酯生成的影响及其与胰岛素抵抗的关系。
生化/生理作用
特点和优势
抗体吸附剂
分析说明
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文献和实验Neural Crest Cells Differentiate Into Brown Adipocytes and Contribute to Periaortic Arch Adipose Tissue Formation.
Periaortic arch adipose tissue (PAAT) plays critical roles in regulating vascular homeostasis; however, its anatomic features, developmental processes, and origins remain unclear. Approach and Results: Anatomic analysis and genetic lineage tracing of Wnt1 (wingless-type MMTV [mouse mammary tumor virus] integration site family member 1)-Cre+;Rosa26RFP/+ mice, Myf5 (myogenic factor 5)-Cre+;Rosa26RFP/+ mice, and SM22α-Cre+;Rosa26RFP/+ mice are performed, and the results show that PAAT has unique anatomic features, and the developmental processes of PAAT are independent of the others periaortic adipose tissues. PAAT adipocytes are mainly derived from neural crest cells (NCCs) rather than from Myf5+ progenitors. Most PAAT adipocyte progenitors expressed SM22α+ (smooth muscle protein 22-alpha) during development. Using Wnt1-Cre+;PPARγflox/flox mice, we found that knockout of PPAR (peroxisome proliferator-activated receptor)-γ in NCCs results in PAAT developmental delay and dysplasia, further confirming that NCCs contribute to PAAT formation. And we further indicated PAAT dysplasia aggravates Ang II (angiotensin II)-induced inflammation and remodeling of the common carotid artery close to aorta arch. We also found that NCCs can be differentiated into both brown and white adipocytes in vivo and in vitro. RNA sequencing results suggested NCC-derived adipose tissue displays a distinct transcriptional profile compared with the non-NCC-derived adipose tissue in PAAT. PAAT has distinctive anatomic features and developmental processes. Most PAAT adipocytes are originated from NCCs which derive from ectoderm. NCCs are progenitors not only of white adipocytes but also of brown adipocytes. This study indicates that the PAAT is derived from multiple cell lineages, the adipocytes derived from different origins have distinct transcriptional profiles, and PAAT plays a critical role in Ang II-induced common carotid artery inflammation and remodeling.Visual OvervieW: An online visual overview is available for this article.
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