ApoE4 (4E4) Mouse mAb

Laser-Capture Microdissection of Hyperlipidemic/ApoE/ Mouse Aorta Atherosclerosis

roles have not been defined. To map these infiltrates, we employed laser-capture microdissection (LCM) to isolate the three arterial wall laminae using apoE−/− mouse aorta as a model. RNA from LCM-separated tissues was extracted and large-scale

Purification of mAb (IgG)

(adjust pH to 7.8 with Binding buffer; red color) to the Protein A column.Mouse antibodies of the IgG1 subclass do not have a high affinity for protein A. Purification on protein A beads using standard conditions will yield approximately 1/10

APOE-Based Models of Pre-Dementia

all past and present attempts to create an APOE-based model with suggestions on how to reproduce AD in a mouse. Our ability to succeed in recreating late-onset AD will depend on the identification of new genetic markers in addition to the validation of nongenetic