- ￥228 - 1898
- 碧云天（Beyotime）
- S1732
- 2026年10月28日
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- 文献和实验
- 技术资料
- 规格：
2mg/ml×0.25ml/5mg/25mg
| 规格： | 2mg/ml×0.25ml | 产品价格： | ￥228.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥468.0 |
| 规格： | 25mg | 产品价格： | ￥1898.0 |
LPS即lipopolysaccharide(脂多糖)，是一种脂质和多糖的复合物。本产品是从E. coli O111:B4 (也称E. coli 0111:B4) 中纯化获得的，可以特异性地激活TLR4，但也有可能会激活TLR2。
LPS是绝大多数革兰氏阴性菌细胞壁的主要成分，有很强的免疫原性。大量的LPS可以诱导机体产生大量炎症因子而发生免疫反应甚至休克，而持续的少量LPS却使机体产生免疫耐受。LPS主要通过TLR4 (Toll-like receptor 4)发挥作用。LPS可以和脂多糖结合蛋白(lipopolysaccharide binding protein, LBP)结合，随后和CD14结合，并和TLR4和MD2形成复合物。该复合物形成后，可以通过MyD88途径诱导炎性细胞因子的产生。LPS的信号途径也可以不依赖于MyD88而介导干扰素诱导基因的表达。此外，LPS的活性成分类脂A(Lipid A)，其不同的形态会影响LPS与TLR的结合。不同来源的LPS的性状有所不同，通常从大肠杆菌来源的LPS可以激活TLR4从而引起炎症反应，而从P. gingivalis 来源的LPS可以激活TLR2从而引起炎症反应。本产品为大肠杆菌(E. coli O111:B4 )来源的LPS。
LPS可以激活NF-κB信号通路，从而促进后续的炎症因子的转录和表达。LPS因此也常用作NF-κB信号通路的激活剂。另外，LPS在肝细胞中可以上调iNOS的水平。
市场上的大多数LPS制剂往往会被其他的细菌成分所污染，例如脂蛋白，因此在激活TLR4信号通路的同时也会激活TLR2信号通路。本产品在激活TLR4信号通路的时候，有可能会激活TLR2信号通路。
从E. coli O111: B4 中纯化获得的LPS是目前应用最广泛的一种LPS。
本产品为进口分装，其中2mg/ml包装用水配制，共0.25ml。5mg和25mg包装为粉末装。
包装清单：
| 产品编号 | 产品名称 | 包装 |
| S1732-0.5mg | LPS(TLR4激活剂) | 2mg/ml×0.25ml |
| S1732-5mg | LPS(TLR4激活剂) | 5mg |
| S1732-25mg | LPS(TLR4激活剂) | 25mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，一年有效。需避免反复冻融，可以适当分装。短时间内频繁使用可以4℃保存，一个月有效。
注意事项：
本产品对人体有害，操作时请小心，并注意有效防护以避免直接接触人体或吸入体内。由于LPS有很强的免疫原性，需注意防止LPS被吸入或进入人体的循环系统。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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文献和实验1. Zhao F, Lei B, Li X, Mo Y, Wang R, Chen D, Chen X . Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes. Biomaterials. 2018 Sep;178:36-47.(IF 10.317)
2. Wen-Hao Li, Jun-Jun Wu, Lie Wu, Bo-Dou Zhang, Hong-Guo Hu, Lang Zhao, Zhi-Bin Li, Xue-Feng Yu, Yan-Mei Li . Black phosphorous nanosheet: A novel immune-potentiating nanoadjuvant for near-infrared-improved immunotherapy Biomaterials. 2021 Jun;273:120788.doi: 10.1016/j.biomaterials.2021.120788.(IF 10.317)
4. Hu Q, Li B, Xu R, Chen D, Mu C, Fei E, Wang G. . The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation. Sci Signal. 2012 Aug 21;5(238):ra61.(IF 6.467)
5. Shuo Zhang, Peng Wang, Binwu Hu, Weijian Liu, Xiao Lv, Songfeng Chen, Zengwu Shao . HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages Front Cell Dev Biol. 2022 Jan 4;9:796974.doi: 10.3389/fcell.2021.796974.(IF 5.201)
6. Zuo QP, Li ZJ, Hu YH, Li B, Huang LH, Wang CJ, Liu SK, Liao HQ. . A Highly Sensitive Fluorescent Probe for HClO and Its Application in Live Cell Imaging. J Fluoresc. 2012 Sep;22(5):1201-7.(IF 2.093)
7. Zhou Y, Zhu N, Wang X, Wang L, Gu LJ, Yuan WJ. . The role of the toll-like receptor TLR4 in hepatitis B virus-associated glomerulonephritis. Arch Virol. 2013 Feb;158(2):425-33.(IF 2.243)
8. Lou T, Jiang W, Xu D, Chen T, Fu Y. . Inhibitory Effects of Polydatin on Lipopolysaccharide-Stimulated RAW 264.7 Cells. Inflammation. 2015;38(3):1213-20.(IF 3.212)
9. Jiang W, Luo F, Lu Q, Liu J, Li P, Wang X, Fu Y, Hao K, Yan T, Ding X. . The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation andoxidative state. CHEM-BIOL INTERACT. 2016 Jan 5;243:127-34.(IF 3.723)
10. Geng T, Lv DD, Huang YX, Hou CX, Qin GX, Guo XJ. . JAK/STAT signaling pathway-mediated immune response in silkworm (Bombyx mori) challenged byBeauveria bassiana. Gene. 2016 Dec 20;595(1):69-76.(IF 2.984)
11. Li Y, Hu N, Yang D, Oxenkrug G, Yang Q. . Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism. FEBS J. 2017 Jan 24.doi: 10.1111/febs.14026. [Epub ahead of print](IF 4.392)
12. Wang N, Tian X, Chen Y, Tan HQ, Xie PJ, Chen SJ, Fu YC, Chen YX, Xu WC, Wei CJ. . Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipidprofiles,and islet morphology and function in db/db mice. SCI REP-UK. 2017 Oct 31;7(1):14707.(IF 3.998)
13. Zhang XF, Weng DS, Pan K, Zhou ZQ, Pan QZ, Zhao JJ, Tang Y, Jiang SS, Chen CL, Li YQ, Zhang HX, Chang AE, Wicha MS, Zeng YX, Li Q, Xia JC. . Dendritic-cell-based immunotherapy evokes potent anti-tumor immune responses in CD105+ human renal cancer stem cells. MOL CARCINOGEN. 2017 Nov;56(11):2499-2511.(IF 3.825)
14. Huang LG, Zou J, Lu QC. . Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiologicalfeatures and cell apoptosis by activating Sestrin-3. Brain Res. 2017 Nov 27. pii: S0006-8993(17)30514-0.(IF 2.733)
17. Yu S, Zeng YJ, Sun XC . Neuroprotective effects of p53/microRNA‑22 regulate inflammation and apoptosis in subarachnoid hemorrhage. Int J Mol Med. 2018 Apr;41(4):2406-2412.(IF 3.098)
18. Ma J, Wang Z, Zhao J, Miao W, Ye T, Chen A . Resveratrol Attenuates Lipopolysaccharides (LPS)-Induced Inhibition of Osteoblast Differentiation in MC3T3-E1 Cells. . Med Sci Monit. 2018 Apr 6;24:2045-2052.
19. Yu S, Zeng YJ, Sun XC. . Neuroprotective effects of p53/microRNA 22 regulate inflammation and apoptosis in subarachnoid hemorrhage. Int J Mol Med. 2018 Apr;41(4):2406-2412.(IF 3.098)
20. Ma X, Yao H, Yang Y, Jin L, Wang Y, Wu L, Yang S, Cheng K. . miR-195 suppresses abdominal aortic aneurysm through the TNF-α/NF-κB and VEGF/PI3K/Aktpathway. Int J Mol Med. 2018 Apr;41(4):2350-2358.(IF 3.098)
21. Luo Q, Zeng J, Li W, Lin L, Zhou X, Tian X, Liu W, Zhang L, Zhang X . Silencing of miR‑155 suppresses inflammatory responses in psoriasis through inflammasome NLRP3 regulation. Int J Mol Med. 2018 Aug;42(2):1086-1095.(IF 3.098)
22. Yanqiang Zou, Cheng Zhou, Heng Xu, Jizhang Yu, Ping Ye, Hao Zhang, Shanshan Chen, Jing Zhao, Sheng Le, Jikai Cui, Lang Jiang, Jie Wu, Jiahong Xia . Glibenclamide ameliorates transplant-induced arteriosclerosis and inhibits macrophage migration and MCP-1 expression Life Sci. 2020 Jan 15;241:117141.doi: 10.1016/j.lfs.2019.117141.(IF 3.647)
23. Yiyi Li, Xuan Niu, Haitao Xu, Qingwen Li, Lanxia Meng, Mingyang He, Jie Zhang, Zhentao Zhang, Zhaohui Zhang . VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis Exp Cell Res. 2020 Apr 1;389(1):111847.doi: 10.1016/j.yexcr.2020.111847.(IF 3.383)
24. Jialing Peng, Hongxuan Wang, Zhe Gong, Xiangpen Li, Lei He, Qingyu Shen, Jingrui Pan, Ying Peng . Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity Mol Immunol. 2020 Jul;123:74-87.doi: 10.1016/j.molimm.2020.04.013.(IF 3.641)
26. Lanlan Nie, Rui Li, Jie Huang, Lingling Wang, Mengjie Ma, Chunyue Huang, Tong Wu, Renjie Yan, Xiao Hu . Abietane diterpenoids from Dracocephalum moldavica L. and their anti-inflammatory activities in vitro Phytochemistry. 2021 Apr;184:112680.doi: 10.1016/j.phytochem.2021.112680.(IF 3.044)
27. Jun Li, Lei Xue, Yunfei Wu, Qiang Yang, Degang Liu, Changhui Yu, Jiangzhou Peng . STAT3-activated lncRNA XIST accelerates the inflammatory response and apoptosis of LPS-induced acute lung injury J Cell Mol Med. 2021 Jul;25(14):6550-6557.doi: 10.1111/jcmm.16653.(IF 4.486)
28. Xin Zhou, Zheng Zhang, Weiwei Jiang, Miao Hu, Yichen Meng, Wenfang Li, Xuhui Zhou, Ce Wang . Naringenin is a Potential Anabolic Treatment for Bone Loss by Modulating Osteogenesis, Osteoclastogenesis, and Macrophage Polarization Front Pharmacol. 2022 May 2:13:872188.doi: 10.3389/fphar.2022.872188.(IF 4.225)
29. Yong Xiang, Yun Yu, Qingbo Li, Jian Chen, Yu Li, Weisheng Cao . Chicken telomerase reverse transcriptase mediates LMH cell pyroptosis by regulating the nuclear factor-kappa B signaling pathway Poult Sci. 2022 Jun;101(6):101826.doi: 10.1016/j.psj.2022.101826.
30. Yijie Jia, Jiaqi Chen, Zhikang Zheng, Yuan Tao, Shuting Zhang, Meina Zou, Yanlin Yang, Meng Xue, Fang Hu, Yang Li, Qian Zhang, Yaoming Xue, Zongji Zheng . Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease Mol Med. 2022 Aug 12;28(1):95.doi: 10.1186/s10020-022-00525-1.(IF 4.096)
complex, LPS:LBP:CD14, which transfers LPS to the toll-like receptor 4 (TLR4) accessory protein MD2 complex. This leads to activation of toll-like receptor-4. LPS activated TRL4 activates the NFkappaB pathway and all three MAPK pathways; ERK, JNK/SAPK
Lipopolysaccharide (LPS) is a major component of the meningococcal outer membrane. It consists of a hexa-acylated glucosamine disaccharide substituted at both ends with diphosphoethanolamine, to which an oligosaccharide chain of up to 10
myz68mrq 想做细胞的Notch调控，常用的Notch激活剂有哪些啊？ zhujoker 有rhNF-κB 参考下面2篇文献： Wnt和notch信号通路在肿瘤干细胞自我更新中的作用 ， myz68mrq 谢谢回复。现在有研究者使用Recombinant Rat Jagged 1 Fc Chimera，作为Notch的激活剂，不知在选择上有何不同？
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