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- GeneTex
- 美国
- GTX135972-pro
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store as concentrated solution. Centrifuge briefly prior to opening vial. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 保质期：
12 months from the shipping date of the product.
- 英文名：
SARS-CoV-2 (COVID-19) Spike (ECD) protein, His tag (active)
- 库存：
Available
- 供应商：
GeneTex
- 规格：
100 μg
Sandwich ELISA detection of recombinant Spike ECD protein(s) derived from different strains of SARS-CoV-2 virus (ie., Wild type; B1.617.2 delta variant; B.1.1.7 alpha variant; B.1.351 beta variant; P.1 gamma variant) using antibodies as below.
Capture: SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1014] (GTX635807) (5 μg/mL)
Detection: HRP-conjugated SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1002] (GTX635791) (1 μg/mL)
Please notice that GTX635791 needs to be conjugated to HRP to function as the detection antibody when paired with GTX635807. Please contact us for custom HRP-conjugated antibody.
Functional ELISA analysis of immobilized recombinant Spike ECD protein(s) derived from different strains of SARS-CoV-2 virus (ie., Wild type; BA.2.12.1 Omicron variant) (coated at 2 μg/mL) binding to soluble recombinant Human ACE2 (ECD) protein, mouse IgG Fc tag (active) (GTX135683-pro) (0.16-117.19 nM). Bound protein was detected by Goat Anti-Mouse IgG antibody (HRP) (GTX213111-01) (1:10000).
Sandwich ELISA detection of recombinant Spike ECD protein(s) derived from different strains of SARS-CoV-2 virus (ie., Wild type; BA.2.12.1 Omicron variant) using antibodies as below.
Capture: SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1014] (GTX635807) (5 μg/mL)
Detection: SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1003] (HRP) (GTX635792-01) (1 μg/mL)
Indirect ELISA analysis performed by coating plate with recombinant Spike ECD protein(s) derived from different strains of SARS-CoV-2 virus (ie., Wild type; B.1.1.7 alpha variant; B.1.351 beta variant; P.1 gamma variant; B1.617.2 delta variant) (29.71-0.46 nM). Coated protein was probed with SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1002] (GTX635791) (1 μg/mL). Goat anti-rabbit IgG antibody (HRP) (GTX213110-01) (1:10000) was used to detect bound primary antibody.
Sandwich ELISA detection of recombinant Spike ECD protein(s) derived from different strains of SARS-CoV-2 virus (ie., Wild type; B.1.1.7 alpha variant; B.1.351 beta variant; P.1 gamma variant; B1.617.2 delta variant) using antibodies as below.
Capture: SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (GTX632604) (5 μg/mL)
Detection: SARS-CoV-2 (COVID-19) Spike S1 antibody [HL263] (GTX635672) (1 μg/mL)
Sandwich ELISA detection of recombinant Spike ECD protein(s) derived from different strains of SARS-CoV-2 virus (ie., Wild type; B.1.1.7 alpha variant; B.1.351 beta variant; P.1 gamma variant; B1.617.2 delta variant) using antibodies as below.
Capture: SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (GTX632604) (5 μg/mL)
Detection: SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1003] (GTX635792) (1 μg/mL)
Indirect ELISA analysis performed by coating plate with recombinant SARS-CoV-2 (COVID-19) Spike ( L18F,..., K417N, E484K, N501Y,...)(ECD) Protein, His tag (active) (South Africa variant) (GTX136061-pro) and SARS-CoV-2 (COVID-19) Spike (ECD) protein, His tag (active) (GTX135972-pro) (4000-62.5 ng/mL). Coated protein was probed with SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1004] (GTX635793) (1 μg/mL). Rabbit IgG antibody (HRP) (GTX213110-01) (1:10000) was used to detect bound primary antibody.
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文献和实验Yuan-Chieh Yeh et al. et al., Front Pharmacol. 2021;12(765553)
Di Domenico M et al., Diagnostics (Basel) 2021 (PMID:33919728)
Lee CY et al., Viruses 2023 (PMID:36992350)
Doan LH et al., Front Pharmacol 2022 (PMID:35860023)
Yuan-Chieh Yeh et al., Front Pharmacol 2021 (PMID:35401158)
Cell Death Differ：中大五院黄曦团队发现新冠病毒引起肺损伤的分子机制
近期，中山大学附属第五医院黄曦团队报道了 SARS-CoV-2 的 membrane (M) 蛋白通过靶向并抑制胞内 BOK 的泛素化降解，激活肺上皮细胞线粒体凋亡途径而引起肺损伤，该发现为 COVID-19 的靶向治疗提供了潜在靶点。 图片来源：Cell death & differentiation SARS-CoV-2 感染已经导致全球数以百万人的死亡，其中大部分死亡患者出现呼吸困难，肺部出现大量凋亡的细胞和渗漏的粘液，已有研究证实 SARS-CoV-2 感染引起肺细胞凋亡参与上述
even at titers below 10 ng/ml9,10. The detection limit is of great concern in the context of IgM or IgA assays for active SARS-CoV-2 infections where false negatives are to be avoided at all costs. Especially patients with asymptomatic or mild disease
5位院士为代表，超12篇CNS大作，5月新冠研究汇总——全方位围攻新冠病毒，值得收藏
的鸡尾酒疗法也引起了大家的关注，不同的抗体可以识别结合域上不同的抗原表位，在未来的临床应用中能够避免免疫逃逸的理想单克隆抗体对。 5 月 8 日，军事医学科学院生物工程研究所陈薇院士团队和西湖大学周强团队强强联合，在预印本平台 bioRxiv 上线题为：A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site
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