Phosphatidylinositol 4-Kinase

产品名称：Phosphatidylinositol 4-Kinase Type 2 Alpha (PI4K2A) Antibody-Phosphatidylinositol 4-Kinase Type 2 Alpha (PI4K2A) Antibody

产品货号：abx033831

产品规格：80ul#400ul

应用类型：WB, IHC, IF/ICC

保存建议：Phosphatidylinositol 4-Kinase Type 2 Alpha (PI4K2A) Antibody-Phosphatidylinositol 4-Kinase Type 2 Alpha (PI4K2A) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs. PI4K II is activated by detergent and inhibited by adenosine. Overexpression of PI4KII in COS-7 cells increases synthesis of PtdIns4P. Some cells overexpressing PI4KII have scattered or no perinuclear Golgi. Knockdown of PI4KII by RNA interference (RNAi) does not disrupt the Golgi, and some cells show expanded Golgi. RNAi reduces the Golgi level of PtdIns4P and blocks the association between AP1 and the trans-Golgi network. PI4KII RNAi had little effect on intra-Golgi trafficking, but it inhibited export to plasma membrane export by 35%. It has been proposed that PI4KII generates PtdIns4P-rich domains within the Golgi that specify docking of the AP1 coat machinery.

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关键词：Phosphatidylinositol 4-Kinase Type 2 Alpha (PI4K2A) Antibody，Phosphatidylinositol 4-Kinase Type 2 Alpha (PI4K2A) Antibody，待更新