Activin A Receptor Type IB Ant

产品名称：Activin A Receptor Type IB Antibody-Activin A Receptor Type IB Antibody

产品货号：abx033689

产品规格：80ul#400ul

应用类型：WB, FCM

保存建议：Activin A Receptor Type IB Antibody-Activin A Receptor Type IB Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The gene for ACVR1B (activin A type IB receptor) is composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

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关键词：Activin A Receptor Type IB Antibody，Activin A Receptor Type IB Antibody，待更新