Ubiquitin C-Terminal Hydrolase

产品名称：Ubiquitin C-Terminal Hydrolase UCH37 (UCH37) Antibody-Ubiquitin C-Terminal Hydrolase UCH37 (UCH37) Antibody

产品货号：abx031537

产品规格：80ul#400ul

应用类型：WB, IHC

保存建议：Ubiquitin C-Terminal Hydrolase UCH37 (UCH37) Antibody-Ubiquitin C-Terminal Hydrolase UCH37 (UCH37) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：Covalent attachment of the C-terminus of ubiquitin to cellular proteins plays a role in a variety of cellular processes. Ubiquitin C-terminal hydrolysis is catalyzed by deubiquitinating (DUB) enzymes and is necessary for several functions, including liberation of monomeric ubiquitin from the precursors encoded by ubiquitin genes and recycling of ubiquitin monomers. There are 2 distinct families of DUBs, ubiquitin-specific proteases (UBPs) and ubiquitin C-terminal hydrolases (UCHs). Mayer and Wilkinson (1989) identified 4 distinct UCH activities from bovine thymus. All 4 were thiol proteases and had high-affinity binding sites for ubiquitin. Wilkinson et al. (1989) purified the predominant isozyme, UCHL3, and raised antibodies against it. By screening a human B-cell expression library with the antibodies, the authors isolated cDNAs encoding human UCHL3. Sequence comparisons revealed that the sequence of the predicted 230-amino acid human UCHL3 protein is 54% identical to that of UCHL1.

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关键词：Ubiquitin C-Terminal Hydrolase UCH37 (UCH37) Antibody，Ubiquitin C-Terminal Hydrolase UCH37 (UCH37) Antibody，待更新