Myeloid Cell Surface Antigen C

产品名称：Myeloid Cell Surface Antigen CD33 (CD33) Antibody-Myeloid Cell Surface Antigen CD33 (CD33) Antibody

产品货号：abx028674

产品规格：80ul#400ul

应用类型：WB, IHC

保存建议：Myeloid Cell Surface Antigen CD33 (CD33) Antibody-Myeloid Cell Surface Antigen CD33 (CD33) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：SIGLEC3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2, 6-linked sialic acid; the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, SIGLEC3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules. This protein Induces apoptosis in acute myeloid leukemia (in vitro). It has been shown to interact with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. SIGLEC3 expresses in monocytic/myeloid lineage cells, and contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6. The gene for SIGLEC3 belongs to the immunoglobulin superfamily.

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关键词：Myeloid Cell Surface Antigen CD33 (CD33) Antibody，Myeloid Cell Surface Antigen CD33 (CD33) Antibody，待更新