Transcription Elongation Facto

产品名称：Transcription Elongation Factor SPT5 (SUPT5H) Antibody-Transcription Elongation Factor SPT5 (SUPT5H) Antibody

产品货号：abx028120

产品规格：80ul#400ul

应用类型：WB

保存建议：Transcription Elongation Factor SPT5 (SUPT5H) Antibody-Transcription Elongation Factor SPT5 (SUPT5H) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

点击：Transcription Elongation Factor SPT5 (SUPT5H) Antibody-Transcription Elongation Factor SPT5 (SUPT5H) Antibody查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询Abbexa中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品网站。

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关键词：Transcription Elongation Factor SPT5 (SUPT5H) Antibody，Transcription Elongation Factor SPT5 (SUPT5H) Antibody，待更新