Protein Phosphatase, Mg2+/Mn2+

产品名称：Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody-Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody

产品货号：abx027662

产品规格：80ul#400ul

应用类型：WB

保存建议：Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody-Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

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关键词：Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody，Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody，待更新