ATPase, Na+/K+ Transporting Al

产品名称：ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1) Antibody-ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1) Antibody

产品货号：abx000792

产品规格：20ul#50ul#100ul#200ul

应用类型：WB, IHC

保存建议：ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1) Antibody-ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：ATP1A1 Antibody is a Rabbit Polyclonal antibody against ATP1A1. The Na,K-ATPase is an integral membrane heterodimer belonging to the P-type ATPase family. This ion channel uses the energy derived from ATP hydrolysis to maintain membrane potential by driving sodium export and potassium import across the plasma membrane against their electrochemical gradients. It is composed of a catalytic α subunit and a β subunit (reviewed in 1). Several phosphorylation sites have been identified for the α1 subunit. Tyr10 is phosphorylated by an as yet undetermined kinase (2), Ser16 and Ser23 are phosphorylated by PKC, and Ser943 is phosphorylated by PKA (3-5). All of these sites have been implicated in the regulation of enzyme activity in response to hormones and neurotransmitters, altering trafficking and kinetic properties of Na,K-ATPase. Altered phosphorylation in response to angiotensin II stimulates activity in the rat proximal tubule (6). Na,K-ATPase is also involved in other signal transduction pathways. Insulin regulates its localization in differentiated primary human skeletal muscle cells, and this regulation is dependent on ERK1/2 phosphorylation of the α subunit (7). Na,K-ATPase and Src form a signaling receptor complex that affects regulation of Src kinase activity and, subsequently, its downstream effectors (8,9).

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关键词：ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1) Antibody，ATPase, Na+/K+ Transporting Alpha 1 Polypeptide (ATP1A1) Antibody，待更新