P16 (Mouse and Human) Antibody

产品名称：P16 (Mouse and Human) Antibody-P16 (Mouse and Human) Antibody

产品货号：abx016046

产品规格：100ul

应用类型：ELISA, WB, IHC

保存建议：P16 (Mouse and Human) Antibody-P16 (Mouse and Human) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：The progression of cells through the cell cycle is regulated by a family of protein kinases known as cyclin-dependent kinases (Cdks).The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle.The cyclins function as differentially expressed positive regulators of Cdks.Negative regulators of the cycle include the p53-inducible 21 kDa WAF1/Cip1 protein designated p21, Kip1 p27 and p16.The complexes formed by Cdk4 and the D-type cyclins have been strongly implicated in the control of cell proliferation during the G1 phase.It has recently been shown that p16 binds to Cdk4 and inhibits the catalytic activity of the Cdk4/cyclin D complex.Moreover, the gene encoding p16 exhibits a high frequency of homozygous deletions and point mutations in established human tumor cell lines.

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关键词：P16 (Mouse and Human) Antibody，P16 (Mouse and Human) Antibody，待更新