- ￥960 - 1600
- Solarbio
- 北京
- K108709P
- 2025年07月10日
- WB
- Rabbit
- Human Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A synthetic peptide of Human MAPKAPK5
- 亚型：
IgG
- 形态：
液体
- 保存条件：
低温
- 克隆性：
Polyclonal Antibody
- 标记物：
MAPKAPK5
- 适应物种：
Human Mouse
- 保质期：
标签为准
- 目录编号：
8550
- 库存：
99
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB
- 浓度：
现询客服
- 抗体英文名：
Anti-MAPKAPK5 Polyclonal Antibody
- 抗体名：
MAPKAP-K5;MK-5;MK5;PRAK;MAP kinase-activated protein kinase 5
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥960.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 英文名称 | Anti-MAPKAPK5 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | MAPKAP-K5;MK-5;MK5;PRAK;MAP kinase-activated protein kinase 5 |
| 稀释比例 | WB 1:1000-3000. |
| 蛋白分子量 | 54kDa |
| Gene ID | 8550 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of Human MAPKAPK5 |
| 亚细胞定位 | Nucleus Cytoplasm |
| Swiss Prot | Q8IW41 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. |
| 应用 | WB |
| 交叉反应 | Human Mouse |
| 规格 | 50ul 100ul |
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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