- ￥960 - 1600
- Solarbio
- 北京
- K108671P
- 2025年07月15日
- IHC
- Rabbit
- Human Mouse Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A synthetic peptide of Human MAP2K7
- 亚型：
IgG
- 形态：
液体
- 保存条件：
低温
- 克隆性：
Polyclonal Antibody
- 标记物：
MAP2K7
- 适应物种：
Human Mouse Rat
- 保质期：
标签为准
- 目录编号：
5609
- 库存：
99
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
IHC
- 浓度：
现询客服
- 抗体英文名：
Anti-MAP2K7 Polyclonal Antibody
- 抗体名：
JNKK2;MAPKK7;MEK;MEK 7;MKK7;PRKMK7;SAPKK-4;SAPKK4;MEK7;mitogen-activated protein kinase kinase 7
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥960.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 英文名称 | Anti-MAP2K7 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | JNKK2;MAPKK7;MEK;MEK 7;MKK7;PRKMK7;SAPKK-4;SAPKK4;MEK7;mitogen-activated protein kinase kinase 7 |
| 稀释比例 | IHC 1:25-100. |
| 蛋白分子量 | 47/52kDa |
| Gene ID | 5609 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of Human MAP2K7 |
| 亚细胞定位 | Cytoplasm Nucleus |
| Swiss Prot | O14733 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE. |
| 应用 | IHC |
| 交叉反应 | Human Mouse Rat |
| 规格 | 50ul 100ul |
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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