STR基因分型检测是目前国内外应用于个体识别和亲子鉴定的主要技术,也是能够较好解决混合样本个体识别问题的技术手段之一。2008年,英国临床分子遗传协会(CMGS)制订了产前诊断标本分子检测母体细胞污染(maternal cells contamination,MCC)的检测规范。在规范中明确建议所有单基因病的产前诊断结果必须包括母体细胞污染的鉴别实验。且鉴别母体细胞污染的实验技术应最少能检测出10%比例的母体细胞污染的产前诊断样本。ACMG和加拿大医学遗传协会(Canadian College of Medical Genetics,CCMG)已经建议产前分子遗传学诊断应当同时平行检测母亲和胎儿组织标本以排除MCC的潜在影响。
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