Safranal藏红花醛,116-26-7

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Safranal

CAS No. : 116-26-7

MCE 国际站：Safranal

产品活性：Safranal 是藏红花 (Crocus sativus) 的主要成分，具有口服活性，是这种香料的独特香气来源。Safranal 具有神经保护和抗炎作用，并有用于帕金森氏病的研究潜力。

研究领域：NF-κB

作用靶点：Keap1-Nrf2

In Vitro: Safranal (10-50 μM; for 1 h) dose-dependently decreases LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs.
Safranal (10-50 μM; for 1 h) inhibits cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Safranal (10, 50 μM; for 1 h followed by stimulation with 1 μg/ml of LPS for 30 min) inhibits the nuclear translocation of NF-κB and AP-1 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.

In Vivo: Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low.

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