Myxothiazol,76706-55-3

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Myxothiazol

CAS No. : 76706-55-3

MCE 国际站：Myxothiazol

产品活性：Myxothiazol 是一种抗真菌抗生素，是线粒体电子传递链复合体 Ⅲ (complex III or bc1 complex) 抑制剂。Myxothiazol 在0.01~3 μg/ml 浓度范围内可抑制许多酵母菌和真菌的生长。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Fungal  |  Mitochondrial Metabolism  |  Antibiotic

In Vitro: Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml.
?Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity.

In Vivo: Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality.

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