Fusicoccin,20108-30-9

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Fusicoccin

CAS No. : 20108-30-9

MCE 国际站：Fusicoccin

产品活性：Fusicoccin (Fusicoccin A)，一种真菌化脓毒素，14-3-3 蛋白相互作用的稳定剂。Fusicoccin 使 H⁺-ATPase/14-3-3 复合物在植物中稳定，保持酶的激活状态。Fusicoccin 还稳定 14-3-3 蛋白与含有 C-末端 14-3-3 识别基序的结合伙伴的相互作用，如 ERα、GPIbα、TASK3、CTFR 和 p53。Fusicoccin 诱导一些癌细胞调亡，并具有抗癌活性。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: Fusicoccin (Fusicoccin A) stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth (EC₅₀=29 mM).
Fusicoccin A activates the plasma membrane H⁺-ATPase by stabilizing its binding to 14-3-3 proteins, which results in water loss and the wilting of infected plants. Fusicoccin A decreases the proliferation and migration of human GBM cell lines in vitro, including several cell lines that exhibit varying degrees of resistance to pro-apoptotic stimuli. The IC₅₀ growth inhibitory concentration of fusicoccin A is 92 µM in the U373-MG cells and 83 µM in the Hs683 glioma cells.

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