HQNO

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HQNO

CAS No. : 341-88-8

MCE 国际站：HQNO

产品活性：HQNO 由 P. aeruginosa 产生的，是一种有效的电子传递链抑制剂，对 complex III 的 K_d 值为 64 nM。HQNO 是许多物种的线粒体 NDH-2 的有效抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Mitochondrial Metabolism

In Vitro: HQNO is a potent inhibitor of mitochondrial type II NADH:quinone oxidoreductase (NDH-2) in many species, including Yarrowia lipolytica, S. cerevisiae, Gluconobacter oxydans, T. gondii, P. falciparum, and S. aureus. HQNO targets the Q-site of NDH-2.
HQNO concentrations are varied from 0 to 100 μM and 0 to 300 μM for wild-type (WT) and I379E C. thermarum NDH-2 variant, respectively to determine IC₅₀ values. WT NDH-2 has an IC₅₀ value of 10.5±1.3 μM HQNO in the presence of 400 μM Menadione (MD). In the presence of 50 μM MD, the IC₅₀ value for HQNO decreases slightly to 7.3±1.2 μM and near complete inhibition (~15% residual activity) is observed with >50 μM HQNO. At 50 μM MD, HQNO inhibition is observed with an IC₅₀ value of 54.3±1.2 μM.

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