β-Amyloid (1-40), FAM-labeled,

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

β-Amyloid (1-40), FAM-labeled

CAS No. : 1678416-08-4

MCE 国际站：β-Amyloid (1-40), FAM-labeled

产品活性：β-Amyloid (1-40), FAM-labeled 是一个 FAM 荧光标记的 β-Amyloid (1-40) 肽 (λ_ex= 492 nm and λ_em= 518 nm)。

研究领域：Others

作用靶点：Others

In Vitro: Apical-to-basolateral exchange across endothelial monolayer of fluorescent Aβ42 (FAM-labeled Human β-Amyloid (1-42) and Fluor^™488-labeled β-Amyloid (1-42)) or scramble Aβ42 (FAM-labeled scrambled β-Amyloid (1-42)) (1-100 μM) is monitored in transendothelial electrical resistance (TEER) during cell monolayer’s formation over time (over 120 min in presence or absence of Aβ24). Human β-Amyloid (1-24) (1 μM) results in H-Aβ42 retention, thus reducing its efflux through the BBB and therefore preventing an efficient mechanism of Aβ42 clearance.
The in vitro BBB model is used to investigate the passage of FAM-labeled or 488-conjugated H-Aβ42 across the endothelial cell monolayer. The addition of fluorescently labeled H-Aβ42 (FAM-labeled Human β-Amyloid (1-42) or Fluor^™ 488-labeled β-Amyloid (1-42)) to the apical side of cell inserts results in effective BBB crossing, FAM-labeled scrambled β-Amyloid (1-42) is not efficiently transcytosed.

相关产品：PEG300  |  SBE-β-CD  |  Corn oil  |  Tween 80  |  Polyethylene glycol 12-hydroxystearate  |  JC-1  |  DTT  |  CFSE  |  Digitonin  |  Lipopolysaccharides  |  Thiazolyl Blue  |  D-Luciferin potassium salt  |  (2-Hydroxypropyl)-β-cyclodextrin  |  Methyl-β-cyclodextrin  |  Biotin  |  Monocrotaline  |  Auxinole  |  Nile Red  |  3X FLAG peptide TFA  |  FLAG peptide  |  Tocofersolan  |  DAPI dihydrochloride  |  Propidium Iodide  |  Cremophor EL  |  Yoda 1  |  IPTG  |  Calcein-AM  |  GsMTx4 TFA

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。