CE-245677,717899-97-3

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CE-245677

CAS No. : 717899-97-3

MCE 国际站：CE-245677

产品活性：CE-245677 是一种有效的，可逆的 Tie2 和 TrkA/B 抑制剂，在细胞体系下，IC₅₀ 值分别为 4.7 和 1 nM。

研究领域：Neuronal Signaling  |  Protein Tyrosine Kinase/RTK

作用靶点：Trk Receptor  |  Tie

In Vitro: CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC₅₀ of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR.

In Vivo: CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%).

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