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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1033769-28-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥589.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥900.0 |
| 规格： | 25 mg | 产品价格： | ￥1500.0 |
| 规格： | 50 mg | 产品价格： | ￥2400.0 |
| 规格： | 100 mg | 产品价格： | ￥4000.0 |
| 规格： | 200 mg | 产品价格： | ￥5363.0 |
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GNF-5837
CAS No. : 1033769-28-6
MCE 国际站：GNF-5837
产品活性：GNF-5837 是一种有效的，选择性的，口服生物利用的泛 TRK 抑制剂，在 Ba/F3 细胞中显示出抗增殖作用 (对 Tel-TrkC, Tel-TrkB 和 Tel-TrkA 的 IC50 值分别为 7 nM，9 nM 和 11 nM)。.
研究领域：Neuronal Signaling | Protein Tyrosine Kinase/RTK
作用靶点：Trk Receptor
In Vitro: GNF-5837 (0.1-500 nM; 72-144 hours; GOT1 cells) treatment decreases cell viability in a time- and dose-dependent manner in GOT1 cells.
?GNF-5837 (5-500 nM; 24 hours; GOT1 cells) causes downregulation of PI3K-Akt-mTOR signaling, Ras-Raf-MEK-ERK signaling.
?GNF-5837 (5-500 nM; 72 hours; GOT1 cells) treatment induces G1 cell cycle arrest.
?GNF-5837 (500 nM; 144 hours; GOT1 cells) treatment increases apoptotic cell death.
In Vivo: GNF-5837 (25-100 mg/kg; oral administration; once daily; for 10 days; mice) treatment inhibits tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.
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文献和实验The UCSC Genome Browser: What Every Molecular Biologist Should Know
to biological research today, and this unit describes some practical applications of the UCSC Genome Browser. Curr. Protoc. Mol. Biol. 88:19.9.1?19.9.28. © 2009 by John Wiley & Sons, Inc. Keywords: UCSC Genome Browser; clones; primers
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