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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1956426-56-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1301.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥558.0 |
| 规格： | 5 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥1520.0 |
| 规格： | 25 mg | 产品价格： | ￥3350.0 |
| 规格： | 50 mg | 产品价格： | ￥4400.0 |
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KN-93 hydrochloride
CAS No. : 1956426-56-4
MCE 国际站：KN-93 hydrochloride
产品活性：KN-93 hydrochloride是可渗透细胞，可逆和竞争性的抑制剂钙调蛋白依赖性激酶II型 (CaMKII) 抑制剂，Ki 为370 nM。
研究领域：Neuronal Signaling | Autophagy
In Vitro: After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H+, K+-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca2+-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.
相关产品：Bioactive Compound Library Plus | Kinase Inhibitor Library | Neuronal Signaling Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | KN-93 | KN-62 | K-252a | NH125 | Trifluoperazine dihydrochloride | DCP-LA | A-484954 | STO-609 | MLCK inhibitor peptide 18 | CaMKII-IN-1 | Autocamtide-2-related inhibitory peptide TFA | Rimacalib | Cabamiquine | DB0614 | Syntide 2 TFA | XST-14 | Autocamtide 2 | Calmodulin-Dependent Protein Kinase II(290-309) acetate | CS587 | A-3 hydrochloride | Autocamtide 2, amide | Autocamtide-3 acetate | Lavendustin C | Sordarin sodium | AC3-I, myristoylated | Autocamtide-2-related inhibitory peptide, myristoylated
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文献和实验3.61 3.38 3.22 3.10 3.00 2.93 2.87 2.77 2.67 2.56 2.44 2.32 2.19 18 19 4.51 3.90 3.56 3.33 3.17 3.05 2.96 2.88 2.82 2.72 2.62 2.51 2.39 2.27 2.13 19 20 4.46 3.86 3.51 3.29 3.13 3.01 2.91 2.84 2.77 2.68 2.57 2.46 2.35 2.22 2.08 20 21 4.42
71 07 32 90 79 78 53 13 55 38 58 59 88 97 54 14 10 4 12 56 85 99 26 96 96 68 27 31 05 03 72 93 15 57 12 10 14 21 88 26 49 81 76 5 55 59 56 35 64 38 54 82 46 22 31 62 43 09 90 06 18 44 32 53 23 83 01 30 30 6 16 22 77 94 39 49 54 43 54 82 17 37 93 23
2.71 2.56 2.45 2.36 2.29 2.24 2.19 2.12 2.06 2.02 1.99 1.96 28 29 4.18 3.33 2.93 2.70 2.55 2.43 2.35 2.28 2.22 2.18 2.10 2.05 2.01 1.97 1.94 29 30 4.17 3.32 2.92 2.69 2.53 2.42 2.33 2.27 2.21 2.16 2.09 2.04 1.99 1.96 1.93 30 32 4.15 3.29 2.90 2.67
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