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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
139298-40-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1210.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥494.0 |
| 规格： | 5 mg | 产品价格： | ￥1098.0 |
| 规格： | 10 mg | 产品价格： | ￥1525.0 |
| 规格： | 25 mg | 产品价格： | ￥3075.0 |
| 规格： | 50 mg | 产品价格： | ￥4538.0 |
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KN-93
CAS No. : 139298-40-1
MCE 国际站：KN-93
产品活性：KN-93是可渗透细胞，可逆和竞争性的抑制剂钙调蛋白依赖性激酶II型 (CaMKII) 抑制剂，Ki 为370 nM。
研究领域：Neuronal Signaling | Autophagy
In Vitro: After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H+, K+-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca2+-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93. KN-93 (10 μM )significantly inhibits the activation of CaMKII/NF-κB signaling induced by elevated glucose, and subsequently decreases the expression of VEGF, iNOS and ICAM-1 in Müller cells.
In Vivo: KN-93 (1 mg/kg/day, i.p.) inhibits retinal vascular leakage induced by diabetes, and suppresses phosphorylation of CaMKII and NF-κB in diabetic retina.
相关产品：Bioactive Compound Library Plus | Kinase Inhibitor Library | Neuronal Signaling Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-diabetic Compound Library | Targeted Diversity Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | KN-93 phosphate | KN-62 | K-252a | NH125 | Trifluoperazine dihydrochloride | DCP-LA | A-484954 | STO-609 | MLCK inhibitor peptide 18 | CaMKII-IN-1 | Autocamtide-2-related inhibitory peptide TFA | Rimacalib | Cabamiquine | DB0614 | Syntide 2 TFA | XST-14 | Autocamtide 2 | Calmodulin-Dependent Protein Kinase II(290-309) acetate | CS587 | A-3 hydrochloride | Autocamtide 2, amide | Autocamtide-3 acetate | Lavendustin C | Sordarin sodium | AC3-I, myristoylated | Autocamtide-2-related inhibitory peptide, myristoylated
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文献和实验1SuoAc5J/PF6yv1GcZlVMply2VVbnZwH+h5RBi6lJV3Lzqkxbh7VMEMel0SptZS0vOZcrls1ZX/j0ixO2tbZbJ5iR/3rp27LCW1lYvD4Jer0hIJSUvZGDz4C8D7Kn+WQkxUNPdBNljxT8RgT2CQKqpsEdyjplGBCICEYGIQETgAEOgLqJYrvRbsVgQ0UuLZDZESgvOHR0KhlyIpEJFJBbNLZrTtmKLNKcJEeZaX3/ZMvmciCq
【共享】某机构发表的核酸相关研究的文章（EST,SNP等），PDF全文下载
of Catalytic Domains in the First Four Modules of the Putative Pederin Polyketide Synthase ChemBioChem 5: 93-98 pdf Ramser J, Winnepenninckx B, Lenski C, Errijgers V, Platzer M, Schwartz CE, Meindl A, Kooy RF, Abidi F, Gibson A, Frank Kooy R, Lubs HA
/tVLxTCiLlhaKFimCJ0+fxlMz9W4Le5J9e/fizJkzEmN/P39oammiRImSaNO2DXr26pX+PW3IZdfj/Su8/eKFYE0dGBQ1gUEOcTTDhQmkPgHWfKT+HqTrGcg8b8HyCIVCKtIBqg43cO1F6HJ8TYvSochj7DzohO6TSkQyPNWGfh7NiA9AFQ1koXdhVr18kRJjKUNTm36aBfsjKMxPU+q2IKqX04kUcEkLhauRO+qu93j+JQAdy4/B8cPpB6fwCrG1tcXZUydw
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