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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2095668-10-1
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1096.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥997.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 25 mg | 产品价格： | ￥2722.0 |
| 规格： | 50 mg | 产品价格： | ￥4356.0 |
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VIT-2763
CAS No. : 2095668-10-1
MCE 国际站：VIT-2763
产品活性：VIT-2763 是具有口服活性的铁转运蛋白 (ferroportin) 的抑制剂，抑制hepcidin 与铁转运蛋白结合，阻滞铁外流。VIT-2763有用于地中海贫血症的潜力。
研究领域：Membrane Transporter/Ion Channel
作用靶点：Ferroportin
In Vitro: VIT-2763 dose dependently reduces the fluorescence polarization signal, indicating that VIT-2763 displaces TMR-hepcidin from ferroportin (IC50 of 24 ± 13 nM).
VIT-2763 induces BLA reporter gene activity with an average EC50 of 140 ± 50 nM, as a consequence of increasing intracellular iron concentrations caused by blocked iron export in HEK293 cells.
VIT-2763 (100 nM) triggers ubiquitination and subsequent internalization and degradation of ferroportin.
In Vivo: VIT-2763 (30, 100 mg/kg, orally twice daily for 36 days) decreases serum iron and prevented liver iron loading in Hbbth3/+ mice.
VIT-2763 did not change the total liver iron.
VIT-2763 (30, 100 mg/kg, orally twice daily for 36 days) significantly corrects anemia and improved RBC parameters in Hbbth3/+ mice. VIT-2763 decreases the percentage of ROS-positive RBCs in Hbbth3/+ mice from 67% to 30%.
VIT-2763 decreases apoptosis and extends the life span of RBCs in Hbbth3/+ mice.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Targeted Diversity Library | Rare Diseases Drug Library | Heterocyclic Compound Library | Apo-Transferrin | Ferroportin-IN-1
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文献和实验【资源】Annual Reviews of Immunology: 1983--2011下载！
Immunity: The Key Role of Phagocytes 2-Stromal Cell–Immune Cell Interactions 3-Nonredundant Roles of Basophils in Immunity 4-Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease 5-Prevention and Treatment
后，即饭前30min及睡前各服1次CBS110mg，用温开水30ml溶解口服。4周后停服Met，改服庆大霉素（GM）80mg片剂，研末化成10ml水溶液口服，仍联用CBS，方法及时间同前，再服4周，共8周为1疗程。全疗程均同时饭后服Vit。E100mg，复合维生素B 2 片，鱼肝油胶丸1粒，3次/d，8周。治疗前和第4周及疗程结束时均作血、尿常规、粪潜血、肝肾功能检查无异常改变。 2 结果 2.1 疗效判定 治愈：溃疡愈合；好转：溃疡＜50％；无效
后，即饭前30min及睡前各服1次CBS110mg，用温开水30ml溶解口服。4周后停服Met，改服庆大霉素（GM）80mg片剂，研末化成10ml水溶液口服，仍联用CBS，方法及时间同前，再服4周，共8周为1疗程。全疗程均同时饭后服Vit。E100mg，复合维生素B 2 片，鱼肝油胶丸1粒，3次/d，8周。治疗前和第4周及疗程结束时均作血、尿常规、粪潜血、肝肾功能检查无异常改变。 2 结果 2.1 疗效判定 治愈：溃疡愈合；好转：溃疡＜50％；无效
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