BC-DXI-843,2421117-98-6

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BC-DXI-843

CAS No. : 2421117-98-6

MCE 国际站：BC-DXI-843

产品活性：BC-DXI-843 是一种有效的特异性 AIMP2-DX2 抑制剂，IC₅₀ 为 0.92 μM，比作用于 AIMP2 (IC50 >100 μM) 选择性高 100 倍以上。BC-DXI-843 有潜力用于 AIMP2-DX2 肺癌的研究。

研究领域：Others

作用靶点：Others

In Vitro: BC-DXI-843 (0.0316-31.6 μM; 72 hours) suppresses cancer cell proliferation in a DX2-dependent manner. The EC₅₀ in A549 cells is 1.20 μM, which is similar to the IC₅₀ for inhibition of DX2. However, no inhibition of WI-26 cells is observed, suggesting that BC-DXI-843 specifically reduces the viability of cancer cells.

In Vivo: BC-DXI-843 (50 mg/kg; intraperitoneally administered; every other day for 15 days) demonstrates in vivo efficacy in a tumor xenograft mouse model (H460 cells).

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