PF-06305591 dihydrate

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PF-06305591 dihydrate

CAS No. : 2703582-76-5

MCE 国际站：PF-06305591 dihydrate

产品活性：PF-06305591 dihydrate 是一种有效的、高选择性的电压门控钠通道 NaV1.8 的阻断剂，其IC₅₀ 值为15 nM。具有良好的临床前体外ADME (吸收、分布、代谢和排泄) 和安全性。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Sodium Channel

In Vitro: PF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability.

In Vivo: PF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC₅₀ multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain.

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