Ilaprazole艾普拉唑钠盐,172152-50-0

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ilaprazole sodium

CAS No. : 172152-50-0

MCE 国际站：Ilaprazole sodium

产品活性：Ilaprazole (IY-81149) sodium，一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H⁺/K⁺-ATPase，在兔壁细胞制剂中的 IC₅₀ 为 6 μM。Ilaprazole sodium 用于胃溃疡的研究。Ilaprazole sodium 也是一种有效的T细胞起源蛋白激酶 (TOPK) 抑制剂。

研究领域：Membrane Transporter/Ion Channel  |  Cell Cycle/DNA Damage

作用靶点：Proton Pump  |  TOPK

In Vitro: On cumulation of 14C-aminopyrine in histamine stimulated parietal cells, the IC₅₀ of Ilaprazole (IY-81149) sodium is 9 nM.

In Vivo: Ilaprazole sodium (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion.
In anesthetized rats, Ilaprazole sodium dose-dependently increases gastric pH which is lowered by histamine infusion. In the case of i.v. injection, the ED₅₀ of Ilaprazole sodium and Omeprazole is 1.2 and 1.4 mg/kg and in the case of i.d. administration, the ED₅₀ of Ilaprazole sodium and omeprazole is 3.9 and 4.1 mg/kg, respectively. Ilaprazole sodium also significantly inhibits pentagastrin-stimulated gastric secretion. Its ED₅₀ is 2.1 mg/kg and that of Omeprazole was 3.5 mg/kg with i.d. administration. In the case of i.v. injection, Ilaprazole sodium is equipotent to Omeprazole. Ilaprazole sodium also inhibits gastric acid secretion strongly in fistular rats. The ED₅₀ of Ilaprazole sodium administered intraduodenally is 0.43 mg/kg and that of omeprazole Is 0.68 mg/kg.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Membrane Transporter/Ion Channel Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Heterocyclic Compound Library  |  Off-patent Drug Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Bafilomycin A1  |  Concanamycin A  |  Omeprazole  |  OTS964 hydrochloride  |  Zinc Pyrithione  |  Abscisic acid  |  Rabeprazole sodium  |  Lansoprazole  |  HI-TOPK-032  |  OTS514  |  Esomeprazole sodium  |  Thonzonium bromide  |  Vonoprazan Fumarate  |  Pantoprazole sodium  |  Caloxin 2A1 TFA  |  Tenatoprazole  |  Tegoprazan  |  Ilaprazole  |  SCH28080  |  Verucopeptin  |  Abeprazan  |  Cephradine  |  Linaprazan  |  Tiludronate disodium  |  Zastaprazan

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds