- ￥380 - 4694
- MedChemExpress(MCE)
- 美国
- HY-W020468
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
DuP 996
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
105431-72-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥836.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥380.0 |
| 规格： | 5 mg | 产品价格： | ￥971.0 |
| 规格： | 10 mg | 产品价格： | ￥1563.0 |
| 规格： | 25 mg | 产品价格： | ￥2934.0 |
| 规格： | 50 mg | 产品价格： | ￥4694.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Linopirdine
CAS No. : 105431-72-9
MCE 国际站：Linopirdine
产品活性：Linopirdine (DuP 996) 是一种具有口服活性的，选择性 M 型 K+ 电流 (IM；Kv7；KCNQ Channels) 抑制剂，IC50 为 2.4 μM。Linopirdine 是 TRPV1 激活剂。Linopirdine 是一种公认的认知增强活性分子，可增加大鼠脑组织中乙酰胆碱的释放。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：Potassium Channel | TRP Channel
In Vitro: Linopirdine (DuP 996) inhibits IC (measured as a medium afterhyperpolarization tail current, ImAHP) with an IC50 of 16.3 μM. Linopirdine (100 μM) weakly inhibits the K+ leak current, IL, the transient outward current, IA, the delayed rectifier, IK, and the slow component of IAHP, by 28, 37, 36 and 52 percent, respectively. The mixed Na+/K+ inward rectifying current, IQ, is essentially unaffected by Linopirdine (IC50>300 μM).
?Linopirdine acts as an agonist of TRPV1 (transient receptor potential vanilloid type 1).
In Vivo: Linopirdine (DuP 996; i.v.; 0.1-6 mg/kg; increasing doses) transiently (10-15 min) and dose-dependently increases MAP by up to 15%.
相关产品：Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Mechanoreceptors Compound Library | Potassium Channel Compound Library | Human Metabolite Library | Heterocyclic Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Ion Channel Compound Library | Nigericin sodium salt | Rosiglitazone | Yoda 1 | Capsaicin | BAPTA-AM | GsMTx4 | Minocycline hydrochloride | EIPA | Probenecid | Diphenyleneiodonium chloride | 2-Aminoethyl diphenylborinate | Branaplam | Amiloride hydrochloride | GSK1016790A | Capsazepine | Rosuvastatin Calcium | HC-067047 | SCH-23390 hydrochloride | HC-030031 | Glibenclamide | Quinidine (15% dihydroquinidine) | ML-SA1 | Tetrandrine | Carbamazepine | GSK2193874 | Adenosine 5′-diphosphoribose sodium | 20(S)-Ginsenoside Rg3 | DCPIB | E-4031
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
