AM12,2387510-84-9

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AM12

CAS No. : 2387510-84-9

MCE 国际站：AM12

产品活性：AM12 抑制镧系元素诱发的 TRPC5 活性，IC₅₀ 为 0.28 μM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

In Vitro: AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A.
AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it.
AM12 also inhibits Ca²⁺ entry evoked by Gd³⁺. AM12 inhibits the Gd³⁺-evoked Ca²⁺ signal with an IC₅₀ of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd³⁺-evoked signal.

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