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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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AQX-435
CAS No. : 1619983-52-6
MCE 国际站：AQX-435
产品活性：AQX-435 是一种有效的 SHIP1 (SH2 domain-containing inositol-5′-phosphatase 1) 激活剂。AQX-435 降低 B 细胞受体 (BCR) 下游 PI3K 活性，诱导恶性 B 细胞凋亡，减少淋巴瘤生长。
研究领域：Metabolic Enzyme/Protease | Apoptosis
作用靶点：Phosphatase | Apoptosis
In Vitro: AQX-435 reduces CLL cell viability in a dose-dependent manner.
AQX-435-induced (5-30 µM; 24 hours) apoptosis is mediated via caspases since AQX435 induced PARP cleavage.
AQX-435 effectively inhibits PI(3,4,5)P3-mediated signaling downstream of the BCR in CLL and DLBCL cells. AQX-435 and Ibrutinib combine effectively to enhanced inhibition of BCR signaling. AQX-435 induced TMD8 cell apoptosis in vitro with an IC50 of ~2 µM. AQX-435 reduces anti-IgM-induced AKT phosphorylation and induces apoptosis in DLBCL cells.
In Vivo: AQX-435 (10 mg/kg; i.p.; 5 days) significantly reduced the volume of TMD8 tumors.
AQX-435 (50 mg/kg; ip) inhibits DLBCL PDX tumors growth.
AQX-435 reduced AKT phosphorylation and growth of DLBCL in vivo and cooperated with ibrutinib for tumor growth inhibition.
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文献和实验In Vitro Functional Study of miR-126 in Leukemia
MicroRNAs (miRNAs, miRs) are postulated to be important regulators in various cancers, including leukemia. In a large-scale miRNA expression profiling analysis of 435 human miRNAs in 52 acute myeloid leukemia (AML) samples, we found that miR
Cell Res,1992,201(2)：417-435. ［5］Tegelenbosch RAJ, De Rooij DG. A quantitative study of spermatogonial multiplication and stem cell renewal in the C3H／101F1 hybrid mouse［J］. Mutation Reserch,1993,290(1)：193-200. ［6］Dym M, Jia MC, Dirami G, et al
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