T-705RMP,356783-08-9

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T-705RMP

CAS No. : 356783-08-9

MCE 国际站：T-705RMP

产品活性：T-705RMP 是 T-705 的磷酸化代谢产物，对宿主细胞 IMP 脱氢酶 (IMPDH) 活性的抑制作用很弱，IC₅₀ 为 601 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Drug Metabolite

In Vitro: T-705 can be converted to T-705RMP and T-705RTP by cellular kinases; Host cell enzymes can differentiate T-705, T-705RMP, and T-705RTP from the natural nucleotides. The level of inhibition of IMPDH by T-705RMP is about 150-fold weaker than that by Ribavirin monophosphate, and it became apparent that the antiviral effect of T-705 is not a result of the inhibition of the cellular enzyme.

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