4'-Hydroxy diclofenac4′-羟基双氯芬酸

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4'-Hydroxy diclofenac

CAS No. : 64118-84-9

MCE 国际站：4'-Hydroxy diclofenac

产品活性：4'-Hydroxy diclofenac 是具有口服活性的 Diclofenac (HY-15036) 通过细胞色素 P450 2C9 (CYP2C9) 的代谢产物。4'-Hydroxy diclofenac 具有抗炎和缓解疼痛作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：Drug Metabolite

In Vivo: A single oral administration of Diclofenac to humanized mice, the unchanged drug in plasma peaks at 0.25 hour and then declines with a half-life (t_1/2) of 2.4 hours. 4'-Hydroxy diclofenac also peaks at 0.25 hour and is undetectable within 24 hours. The plasma concentration of unchanged 4'-Hydroxy diclofenac peaks at 0.25 hour and declines rapidly in Humanized chimeric mice received of 4'-Hydroxy diclofenac (10 mg/kg; a single oral).

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