CUDA,479413-68-8

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CUDA

CAS No. : 479413-68-8

MCE 国际站：CUDA

产品活性：CUDA 是一种有效的可溶性环氧水解酶 (sEH) 抑制剂，对小鼠 sEH 和人 sEH 作用的 IC₅₀ 分别为 11.1 nM 和 112 nM。CUDA 能选择性地上调过氧化物酶体增殖激活受体 PPARalpha 的活性。CUDA 可能对心血管疾病的研究有价值。

研究领域：Metabolic Enzyme/Protease  |  Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor

作用靶点：Epoxide Hydrolase  |  PPAR

In Vitro: CUDA (10 μM; 18 hours) produces 6- and 3-fold increases of PPARalpha in COS-7 cells.
CUDA does not alter PPARalpha protein expression, and it competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, suggesting that it functions as a PPARalpha ligand.

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