RAS inhibitor Abd-7,2351843-48

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RAS inhibitor Abd-7

CAS No. : 2351843-48-4

MCE 国际站：RAS inhibitor Abd-7

产品活性：RAS inhibitor Abd-7 是一种有效的 RAS 结合物 (K_d=51 nM)，是 RAS 效应蛋白相互作用 (RAS-effector protein-protein interaction) 的抑制剂。RAS inhibitor Abd-7 与细胞内 RAS 相互作用，阻止 RAS-效应因子相互作用，抑制内源性 RAS 依赖性信号传导。RAS inhibitor Abd-7 破坏了突变体 KRAS 蛋白与 PI3K、CRAF 和 RALGDS 以及 NRAS Q61H 和 HRAS G12V 的蛋白-蛋白相互作用。

研究领域：GPCR/G Protein

作用靶点：Ras

In Vitro: RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range.

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