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RAS inhibitor A
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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
货期:1-2天
MedChemExpress LLC
2351843-48-4
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 2351843-48-4
MCE 国际站:RAS inhibitor Abd-7
产品活性:RAS inhibitor Abd-7 是一种有效的 RAS 结合物 (Kd=51 nM),是 RAS 效应蛋白相互作用 (RAS-effector protein-protein interaction) 的抑制剂。RAS inhibitor Abd-7 与细胞内 RAS 相互作用,阻止 RAS-效应因子相互作用,抑制内源性 RAS 依赖性信号传导。RAS inhibitor Abd-7 破坏了突变体 KRAS 蛋白与 PI3K、CRAF 和 RALGDS 以及 NRAS Q61H 和 HRAS G12V 的蛋白-蛋白相互作用。
研究领域:GPCR/G Protein
作用靶点:Ras
In Vitro: RAS inhibitor Abd-7 (0-20 μM; 24-48 hours) is a cell-potent inhibitor affecting the viability of cancer cell lines in a single digit to low micromolar range.
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