Iodophenpropit dihydrobromide

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Iodophenpropit dihydrobromide

CAS No. : 145196-87-8

MCE 国际站：Iodophenpropit dihydrobromide

产品活性：Iodophenpropit dihydrobromide 是一种有效的选择性组胺 H3 受体 (histamine H3 receptor) 拮抗剂。[¹²⁵I] Iodophenpropit 结合 H3 受体具有选择性，可饱和，易于可逆，及高亲和力 (K_D 为 0.32 nM)。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor.
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC₅₀ of 1.57±0.3 μM.

In Vivo: Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits.

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